Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"deadenylylation"”.
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Studies of protein complexes involved in the adenylation cascade of the nitrogen signalling pathway in Escherichia coli.
… that catalyses the opposing adenylylation and deadenylylation of glutamine synthetase (GS). The overall aim of this thesis was elucidation of the molecular mechanisms of the adenylylation cascade. A new central domain has been identified using ATase truncation constructs in activity assays and …
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Elucidation of the reaction mechanisms involved in the catalysis mediated by glutamine synthetase in Escherichia coli
… a possible mechanism by which the adenylylation/deadenylylation of the enzyme affects the enzyme specificity for either MgATP or Mn2ATP and NH4+ or NH3, is by switching between two putative serine protease-like catalytic triads. Site-directed mutagenesis of a number of residues identiï¬ ed as …
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Post-translational regulation of BiP by FICD-mediated AMPylation and deAMPylation
Regulation of the amount and activity of Binding Immunoglobulin Protein (BiP) contributes to protein-folding homeostasis. BiP’s abundance is modulated transcriptionally by the canonical unfolded protein response (UPR). Conversely, a metazoan-specific, endoplasmic reticulum (ER)-resident, Fic domain …