Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"deacetylation"”.
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Characterization of the histone deacetylation activity of the yeast silencing gene SIR2
A gene's location in the genome can have profound effects on its ekpression. In Saccharomyces cerevisiae, the gene SIR2 is crucial for silencing at the HM mating type loci, the telomeres, and the rDNA array. It is also necessary for maintaining a hypoacetylated state of the histones at these …
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Modification and Translocation of the Biofilm Exopolysaccharide Poly-β(1,6)-N-acetyl-D-glucosamine
… (PNAG). The modification of PNAG through deacetylation and/or hydrolysis by PgaB, BpsB, and IcaB is required for biofilm formation by Escherichia coli, Bordetella bronchiseptica, and Staphylococcus epidermidis, respectively. E. coli PgaB is a two-domain outer membrane lipoprotein that …
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Structural and Metabolic Studies of Glycosaminoglycans (Sulfatase, Hydrazine, Mucopolysaccharidosis)
… was developed. The reaction scheme involved N-deacetylation of the N-acetylhexosamine residues with hydrazine (N(,2)H(,4)) followed by nitrous acid (HONO) cleavage of the polymer at pH 4.0. Initial studies with heparin-derived model compounds indicated that ester and N-sulfate substituents were …
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Chitosan-Cellulose Nanocrystal Polyelectrolyte Complex Particles: Preparation, Characterization, and In Vitro Drug Release Properties
… 3·103, 6·103 kDa) and four different degrees of deacetylation (77, 80, 85, 89%) were used. PEC formation was studied by turbidimetric titration. PEC particles were characterized by FT-IR spectroscopy, scanning electron microscopy, dynamic light scattering, and laser Doppler electrophoresis. The …
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Performance of a multiple stage hot water pretreatment on sugarcane bagasse and its economic analysis
… The modified three-stage pretreatment process (deacetylation, hot water pretreatment and disk milling) was evaluated for corn stover and sugarcane bagasse. Two thirds of the acetyl groups present in the biomass were removed by deacetylation and acetic acid released during hot water pretreatment …
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A Bayesian Approach to Dose-Response Assessment and Drug-Drug Interaction Analysis: Application to In Vitro Studies
… effect of DNA methylation inhibitors and histone deacetylation inhibitors in human ovarian cancer cell lines. The hypothesis is that the combination of DNA methylation inhibitors and histone deacetylation inhibitors will enhance antiproliferative activity in human ovarian cancer cell lines …
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Depression of pyrite in polymetallic sulfide flotation using chitosan-grafted-polyacrylamide polymers
… characteristics of Chi-g-PAM (i.e., degree of deacetylation, weight ratio of chitosan: acrylamide, and dosage) showed that concentrates with least iron grade (3.06%) and recovery (15.33%) could be produced at 85g/t of Chi-g-PAM synthesized from chitosan of 95% degree of deacetylation and 1:4.5 …
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Histone modification and the epigenetics of X chromosome inactivation
… during a time period of concurrent core histone deacetylation supporting a functional role to the level of lysine methylation. I have used cases of X;autosome translocation to examine how these modifications relate to late replication and transcriptional silencing. Results show that whilst the …
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CHARACTERISING A ROLE FOR ACETYLCOENZYME A SYNTHETASE 2 IN THE REGULATION OF AUTOPHAGY
… be directly regulated by protein acetylation and deacetylation. Therefore, it was reasoned that the availability of AcCoA, via the modulation of AcCoA generating enzymes, may regulate autophagy. This study has focussed on the role of the acetate-mediated route to nuclear-cytosolic AcCoA synthesis, …
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An investigation of the factors affecting the degradation of cellulose acetate artefacts in museum collections
… occurring and high levels of acetate indicate deacetylation is occurring. Non-destructive and destructive sampling for ion chromatography have been used to explore if this is a viable screening process to identify artefacts in the early stages of degradation. Chain scission has been …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… of gene expression, DNA methylation and histone deacetylation, both of which are important for MeCP2's function as a transcriptional repressor. Using inhibitors of DNA methyltransferases, we discovered that synaptic activity-dependent decreases in DNA methylation occur in post-mitotic neurons, …
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A histone H4 code regulates 53BP1-mediated responses to DNA damage
… in vivo is demonstrated by my finding that K16 deacetylation accompanies the induction of H2A.X phosphorylation, a well-known marker for DDR, following DNA damage by either UV irradiation, hydroxyurea or bleocin treatment. Moreover, the effects of expressing K16 mutants of H4 and inhibition of …
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Regulation of Gene Transcription by Estrogen Receptor Alpha: The Role of Cis Elements and Trans -Acting Factors
… associated with chromatin remodeling, histone deacetylation, and transcription repression as proteins associated with the DNA-bound ERalpha. We have demonstrated that RbAp46 and RbAp48 interact with ERalpha in vitro and in vivo, associate with ERalpha at endogenous estrogen-responsive genes, …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… analyses indicated that the inhibition of deacetylation pathways altered the yeast’s transcriptional response to antifungal treatment. An in vivo insect infection model also suggested that histone deacetylase inhibitor treatment, in combination with the established antifungal fluconazole, …
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Investigations of the chemistry of taxol
… This is the first disclosure of the C-4 deacetylation of taxol carrying an intact C-13 side chain. Several oxetane ring opened taxol analogs were synthesized via reaction of taxol with electrophilic reagents. The reaction of these oxetane ring-opened analogs have revealed some interesting …
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The Pathophysiological Importance of Nicotinamide Phosphoribosyltransferase as a Key NAD Biosynthesis Enzyme in Metabolic Homeostasis
… understood yet. Here, we have demonstrated that deacetylation on NAMPT by SIRT1 controls its secretion from adipocytes. iNAMPT is acetylated in both brown and white adipose tissues, and the level of acetylation of iNAMPT is decreased during fasting when Sirtuins are activated. We also found that …
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The self-assembly of chitin nanocrystals into hierarchically structured functional materials
… to increase the surface charge by means of deacetylation while maintaining the nanoparticle dimensions unaffected, providing evidence that too high surface charge hinders the self-assembly. On the other hand, the process of deacetylation if applied on chitin before the acidic hydrolysis, …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… SIRT1 activators that promote HDAC1 deacetylation also mitigate neuronal loss in a mouse model of neurodegeneration. I propose that the interaction between SIRT1 and HDAC1 constitutes an essential step in the DNA damage response that could be exploited to enhance neuronal survival in …
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Synthesis and characterization of lignin-carbohydrate block copolymers
… cellulose triacetate under conditions that deacetylation is prevented. • Reaction of this block with 2,4 toluene diisocyanate (TDI) to form an isocyanate-capped CTA prepolymer under conditions that chain extension is limited and a sufficient NCO equivalent/mole is achieved (ie: 1 or 2). • …
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