Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 844 for “"de-novo"”.
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De Novo Heme Protein Design
"We have developed an interesting hypothesis for Olfactory Receptor (OR) mechanism. We are so sensitive to thiols and amines that the most natural way to explain this is that OR is a metalloprotein. We have found a consensus sequence ""HXXCE"" in the 4--5 loop of ORs, which not only binds strongly …
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Towards designing de novo (1--->4)-linked polysaccharides
… of industrial applications ranging from biodegradable materials to pharmaceutical drug carriers. Small functional groups, such as hydroxyl, amine, N-acetylamide and methoxy are commonly employed for creating de novo saccharides with enhanced functionality. The physiochemical properties of …
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Capsid catalysis : de novo enzymes on viral proteins
Biocatalysis has grown rapidly in recent decades as a solution to the evolving demands of industrial chemical processes. Mounting environmental pressures and shifting supply chains underscore the need for novel chemical activities, while rapid biotechnological progress has greatly increased the …
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Generative Diffusion Models Towards De Novo Protein Design
De novo protein design aims to generate proteins with desired functions by rationally engineering novel protein structures and sequences. The structure requires modeling continuous 3D coordinates of atoms with rigid biochemical constraints of the polymer chain while the sequence is a series of …
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De novo design of protein binders as functional therapeutics
De novo design of protein binding proteins (minibinders) with target structure information alone remains a grand challenge. A general computational design framework includes (1) generation of binder backbones, (2) sequence design and side-chain refinement, (3) resampling, and (4) prediction of …
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De Novo Protein Structure Modeling and Energy Function Design
… algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein conformation, as well as select native or native-like structures from numerous possible conformations. An efficient search algorithm must be able to …
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De novo designs of programmable toehold-mediated transcriptional attenuators
… to construct a diverse array of biological devices. RNA-only genetic circuitry provides several advantages over other types of genetic circuitry. While numerous transcriptional activation systems exist, there is a lack of tunable and orthogonal systems capable of transcriptionally …
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The De Novo Biosynthesis of Glycogen in Aerobacter Aerogenes
Made available in DSpace on 2014-12-09T17:36:12Z (GMT). No. of bitstreams: 1 6910707.pdf: 4013519 bytes, checksum: 2bc5dc62c905dd6c1bd8b7a6357a9691 (MD5) Previous issue date: 1968
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Empirical investigation of de novo mutations conferring herbicide resistance
… a predictable natural selection process, herbicides select for adaptive alleles that allow weed populations to survive. These resistance alleles may be available immediately from the standing genetic variation within the population, as well as, may immigrate via pollen or seeds from other …
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Enabling tools for de-novo single molecule protein sequencing
… in protein structure and function can cause deleterious effects and, in cases of critical protein units, precipitate large-scale biological dysfunction. Amino acids are the fundamental building block of proteins, ultimately determining protein folding structure and functionality. As such, the …
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A DE NOVO COMPUTATIONAL DISCOVERY PLATFORM FROM RNA TO PROTEIN
Data-driven identification and functional characterization of human transcripts and proteins remain challenging tasks in the post-genomics era. Transcriptional and post-transcriptional regulation mechanisms hugely increase RNA isoform diversity, while their contribution to protein synthesis remains …
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Molecular Characterization of Mammalian De Novo DNA Methyltransferase Chromatin Recruitment
<p>Precise deposition of CpG methylation is critical for mammalian development and tissue homeostasis and is often dysregulated in human diseases. The genomic localization of de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) is facilitated in part by chromatin "reader" domains to establish …
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Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
… multiple processes. They are formed through <em>de novo</em> and salvage pathways found in cells across the phylogenetic tree. The substrates of enzymes within <em>de novo</em> purine synthesis are known to influence other processes within the cell, such as energy homeostasis. In humans, <em>de …
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De Novo Design of secondary structures: Synthesis and conformational studies
… unique in their ability to adopt compact, well-ordered conformations, and specific folding provides precise spatial orientation of the functional groups that comprise the “active site”. These features suggest that identification of new polymer backbones with discrete and predictable folding …
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Improving de novo molecule generation for structure-based drug design
*De novo* molecule generation for drug design has seen a resurgence in recent years, mostly due to the rapid advances in machine learning (ML) algorithms that utilise deep neural networks, resulting in a plethora of ML-based generative models. However, there is often a large disparity in published …
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Dietary amino acids and their contribution to de novo lipogenesis
The alarming increase in the incidence of the metabolic syndrome is the result of the nutrition transition featuring dietary patterns high in sugars, particularly liquid carbohydrates in the form of sugary beverages, fat, and protein from red meat. The aim of this thesis was to investigate the …
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Engineering of tools for De Novo Assembly of Human Cells
… the shortage will likely become exacerbated. For decades, the field of tissue engineering has developed innovative methods to generate model tissues de novo. Top-down approaches, such as microfluidics and 3D bioprinting, provide spatial control by patterning cell types with high resolution, but …
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Error Correction and de novo Genome Assembly of DNA Sequencing Data
The ability to obtain the genetic code of any species has caused a revolution in biological sciences. Current technologies are capable of sequencing short pieces of DNA with very high quality. These short pieces of DNA determint the sequence of bases in the genome of any species. This information …
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Protein Composition and Subcellular Localization of the De Novo Lipogenic Metabolon
Pages 11-34 are incorrectly numbered as pages 9-32, and pages 35-124 are incorrectly numbered as pages 34-123.
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Uncovering Biophysical Determinants Of Oxidoreductase Function Through De Novo Protein Design
Oxidoreductases are a diverse class of enzymes defined by their chemical role of transferring electrons from one substrate to another. Comprising the functional cores of photosynthetic, chemosynthetic, and cellular respiratory machinery, “redox proteins” and the catalysis they enable form the …
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