Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"de novo purine synthesis"”.
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Cellular and Organismal Ramifications of de novo Purine Synthesis Dysregulation
<p>Purines are a class of nitrogenous bases and are essential small molecules to life. Purines are used within the cell as genetic information carriers, energy currency, signaling molecules, and cofactors for multiple processes. They are formed through <em>de novo</em> and salvage pathways found in …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
… stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via treatment with L-Alanosine (ALA), an inhibitor …
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Investigating The Role Of Chaperone-Mediated Autophagy In Glioma Stem Cells
… common and lethal form of primary brain cancer. Despite the current standard-of-care therapies, glioblastoma remains universally fatal with median survival of less than 2 years. Cancer stem/propagating cells (CSCs) are functionally defined by the enriched capacity to propagate tumors in vivo, as …
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Dynamic Regulation of Metabolism in Archaea
… faced by organisms across all domains of life. Despite fluctuating environments, cells must produce the same metabolic outputs to thrive. Although much is known about the regulation of metabolism in the bacteria and the eukaryotes, relatively little is known about the regulation of metabolism in …
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Functional and Therapeutic Relevance of MTAP Deletion in Glioblastoma
… improvement in outcomes over the past several decades. Understanding of the molecular characteristics of GBM, however, has improved dramatically, with genetic, epigenetic, and transcriptomic classifications now able to divide GBM into subtypes that provide prognostic information and guide the …
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Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents
… work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, <em>et. al</em>. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be …