Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"de novo prediction"”.
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De novo prediction of the ground state structure of transition metal complexes.
… the main goals of computational methods is to identify reasonable geometries for target materials. Organometallic complexes have been investigated in this dissertation research, entailing a significant challenge based on transition metal diversity and the associated complexity of the ligands. A …
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Structure-based realignment of non-coding RNAs in multiple whole genome alignments
… sequence analysis. A major application is the de novo prediction of non-coding RNAs (ncRNAs) from structural conservation visible in the alignment. However, current methods for constructing genome alignments do so by explicitly optimizing for sequence similarity but not structural similarity. …
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Genomics and Transcriptomics Analysis of the Asian Malaria Mosquito Anopheles stephensi
… Middle East. An. stephensi is emerging as a model for molecular and genetic studies of mosquito-parasite interactions. Here we conducted a series of genomic and transcriptomic studies to improve the understanding of the biology of Anopheles stephensi and mosquito in general. First we reported …
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Decoding Human T Cell Immunity With Single-Cell Multi-Omics
… longitudinal infectious disease studies, I identify transient T cell states after infection and link these phenotypes with specific TCR sequences. In the first chapter, I provide a comprehensive overview of the field's state-of-the-art, encompassing experimental single T cell profiling …
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The Role of Phytophthora Secreted Effectors in Determining Pathogen Host Range
… and 515 P. capsici RXLR effector genes and defined families on the basis of sequence similarity. I found that the P. infestans and P. capsici RXLR complements are mostly species-specific. To investigate the role of ETI in nonhost resistance, 48 P. capsici and 82 P. infestans RXLR were …
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Ancestral Genome Reconstruction in Bacteria
… of numerous sequenced genomes has provided a golden opportunity for ancestral state reconstruction studies, especially in the whole genome reconstruction area. However, most ancestral genome reconstruction methods developed so far only focus on gene or replicon sequences instead of whole …
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Applying integrative computational models to study the evolution of gene regulation
… to gene regulation and build statistical models to make quantitative predictions. The evolutionary process has left all kinds of traces in the current biological systems. The study of the evolution of gene regulatory networks in comparable cell types across species is an efficient method to …