Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"de novo gene"”.
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DNA as a programmable material : de novo gene synthesis and error correction
Deoxyribonucleic acid (DNA), the polymeric molecule that carries the genetic code of all living organisms, is arguably one of the most programmable assembly materials available to chemists, biologists, and materials scientists. Scientists have used DNA to build many different structures for various …
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Integrating biclustering techniques with de novo gene regulatory network discovery using RNA-seq from skeletal tissues
In order to improve upon stem cell therapy for osteoarthritis, it is necessary to understand the molecular and cellular processes behind bone development and the differences from cartilage formation. To further elucidate these processes would provide a means to analyze the relatedness of bone and …
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Comparative gene identification in mammalian, fly, and fungal genomes
… step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that have been conserved by natural selection over millions of years of evolution. I develop …
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Synthesis and error correction methods in gene fabrication
Gene Fabrication technology involves the development and optimization of methods relevant to the in vitro synthesis of any given target gene sequence(s) in the absence of template. The driving purpose of this field of research is to bring about the capability for on-demand fabrication of a DNA …
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Resource Allocation and Process Improvement of Genetic Manufacturing Systems
… in molecular and synthetic biology through de novo gene synthesis are stimulating new vaccines, pharmaceutical applications, and functionalized biomaterials, and advancing the knowledge of the function of cells. This evolution in biological processing motivates the study of a class of …
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Photoelectromechanical synthesis of low-cost DNA microarrays
Recent advances in de novo gene synthesis, library construction, and genomic selection for target sequencing using DNA from custom microarrays have demonstrated that microarrays can effectively be used as the world's cheapest sources of complex oligonucleotide pools. Unfortunately, commercial …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
New experiences are encoded in a fragile short-term form of memory, but with time these memories can be converted into a stable long-term form of memory through a process known as memory consolidation. Whereas post-translational modification of existing proteins may be sufficient for short-term …
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On the Origins of Genetic Novelty in Drosophila
… which variants survive and even thrive across generations, and why? Behind this lies the fundamental question of the origins of novelty, for there cannot be variation without a source of new variants. Understanding how novelty emerges, then, is a crucial problem of basic relevance in …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… In many cases, a more comprehensive understanding of the molecular basis underlying disease progression and therapeutic failure is still required to devise new strategies for improving patient outcomes. Technological advancements in biomedical research, especially in single-cell omics …
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Creating sense from non-sense DNA: de novo genesis and evolutionary history of antifreeze glycoprotein gene in northern cod fishes (gadidae)
… waters. AFGPs protect the fish from freezing death by binding to ice crystals and arresting ice growth within the fish. How and from where this important new genetic trait evolved in the gadid genome remained unknown, as thus far there are no homologous sequences in databases to infer genetic …
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Computational Insights into Evolutionary Dynamics of Human and Primate Genes
The evolutionary history of genes across different species is a subject of research interest. For human genes, there is a particular focus on investigating the possible origins of genes. However, there has been limited research on the development process from an evolutionary perspective. …