Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"de novo fatty acid synthesis"”.
-
Activity and mRNA abundance of enzymes for fatty acid synthesis and desaturation in mammary cell cultures
The effect of exogenous unsaturated fatty acids on cellular fatty acid biosynthesis in mammary cells was examined. Under normal situations, even though the diet of a dairy cow contains considerable amounts of unsaturated fatty acids, viz. oleic acid (18:1) and linoleic acid (18:2), the major …
-
ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
Deregulation of cellular metabolism has emerged as a hallmark of cancer yet few therapies targeting cellular bioenergetics are utilized in the clinic. A host of cancer types are known depend on de novo fatty acid synthesis to support aberrant proliferation and survival with prostate cancer being a …
-
Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… are membrane protrusions that facilitate matrix degradation and cellular invasion. Although cellular lipids have been implicated in several aspects of invadopodia assembly and function, the contribution of de novo fatty acid and phospholipid synthesis has not been elucidated. The data in this …
-
A four-cysteine zinc finger in carboxyltransferase structurally links the functions of enzymatic activity and negative feedback regulation of translation
… carboxylase is the first and committed step of de novo fatty acid synthesis in all organisms. In Escherichia coli, the enzyme is expressed as separate proteins for the three functional components: a biotin carboxylase, a biotin carboxyl carrier protein, and a carboxyltransferase. The …
-
Influence of in vitro elaidic acid or trans-vaccenic acid uptake and lactogenic hormone stimulation on fatty acid content of mouse mammary cells
… study was to examine the effects of trans-9-octadecenoic acid (elaidic) and trans-II-octadecenoic acid (trans-vaccenic) on uptake and alteration of exogenous fatty acids by mouse mammary epithelial cells. Cells from a subclone of the COMMA-D cell line were plated on uncoated plastic petri dishes …
-
The Role of Pyruvate Dehydrogenase in Cell Growth
… oxidation, indicating activity of pyruvate dehydrognase (PDH), which gates entry of glucose derived carbon into the tricarboxylic acid (TCA) cycle. To test whether cells require glucose oxidation for proliferation, the work in this thesis establishes a model wherein PDH activity is …
-
Protein kinases in hormonal regulation of adipocyte metabolism.
… when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of …
-
Regulation of glucose -6 -phosphate dehydrogenase by polyunsaturated fatty acids in cultured rat hepatocytes
The goal of this research is to understand the molecular mechanism(s) by which polyunsaturated fatty acids inhibit gene expression of the lipogenic enzymes. The model enzyme which we are using to study this phenomenon is liver glucose-6-phosphate dehydrogenase (G6PD). In order to determine if …
-
Studi ed approfondimenti sulla composizione in acidi grassi del latte bovino di razza Reggiana con diverso fenotipo per k-caseina e Beta-lactoglobulina
… between milk protein polymorphism and fatty acids profiles of bovine milk. Milk samples were collected from each of 55 Reggiana cows during early, mid and late lactation, respectively, in two farms within the production area of Parmigiano Reggiano cheese. Identification and …
-
Effects of Maturity at Harvest of Triticale and Dietary Forage Inclusion on Production Performance, Nutrient Utilization, and Milk Fatty Acid Profile of Lactating Dairy Cows
… 1 of 4 diets in a replicated 4 × 4 Latin square design with 21-d periods. Cows were fed once daily (10:00 a.m.) using a Calan gate system (American Calan Inc., Northwood, NH). Diets included BS or SDS triticale silage with dietary forage inclusion of 54% (high-forage; HF) or 36% (low-forage; LF). …
-
Stearoyl-COA Desaturase Gene Transcription, mRNA, And Activity In Response To Trans-Vaccenic Acid And Conjugated Linoleic Acid Isomers
Studies were conducted to investigate: 1) desaturation of dietary trans-vaccenic acid (TVA, trans11-18:1) to the cis9,trans11-18:2 isomer of conjugated linoleic acid (9/11CLA), 2) effects of two conjugated linoleic acid isomers [9/11CLA or trans10,cis12-18:2 (10/12CLA)] and TVA on enzyme activities …
-
Alterations in Mammary Gland Synthesis and Secretion of Fatty Acids in Response to Trans Isomers of Octadecenoic Acid or Conjugated Linoleic Acid Isomers
… soybean meal, 3) plasma and milk fatty acid profiles of lactating cows in response to a conjugated linoleic acid (CLA) mixture infused into the rumen, and 4) effects of cis9,trans11-18:2 (9/11CLA) or trans10,cis12-18:2 (10/12CLA) on de novo synthesis and desaturation of milk fatty …