Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"dacarbazine"”.
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Preparation of polysaccharide-based nanoemulsions to reduce melanoma drug resistance and inflammation markers
… enabled the delivery of doxorubicin and dacarbazine to A375 cells and diminished cell viability to 14 and 48% for doxorubicin and dacarbazine loaded nano-emulsions, respectively. Furthermore, BMS470539-dihydrochloride [DTrp8]-γ-MSH loaded nano-emulsions were able to decrease the …
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An investigation into the synergistic action of chemotherapy and photodynamic therapy in resistant skin cancers
… the concentration of the chemotherapeutic drug dacarbazine (DTIC) causing fifty percent decrease in melanoma cell viability (LD50), then to investigate the possible synergism of hypericin activated-photodynamic therapy in reducing (HYP-PDT) melanoma cell viability, when combined with …
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Targeting Nrf2 in Inflammation and Cancer
… comparison with melanocytes. Chemoresistance to dacarbazine, doxorubicin and cisplatin correlated with Nrf2 expression, and Nrf2 siRNA increased the susceptibility of M202 and SK-MEL-5 cells to cisplatin, suggesting that Nrf2 plays a role in chemoresistance in melanoma. In conclusion, this study …
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… O6-methylating anticancer drugs procarbazine, dacarbazine, and temozolomide generate O6-MeG adducts, while a thiopurine antimetabolite 6-thioguanine (6-thioG) generates S6-MeG DNA adducts. Instead of pairing with cytosine, these modified guanines mispair with thymine during DNA replication. The …
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Study Of The Photodegradation And Photostability Of Anti-Cancer Drugs In Different Media Towards The Development Of Both New Actinometers And Liquid Formulations
… anti-cancer drugs will be employed as models; Dacarbazine (DBZ) has well established photostability issues, Axitinib (AXI) and Sunitinib (SUT) are two new drugs only commercially available in solid dosage forms. In ethanol, the photokinetics of these drugs were well described by the newly …
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Development of a new actinometric method for polychromatic light irradiation. Application to photochromes, drugs and stilbenoids
… AB 〖(1Φ)〗_(ε_(B=0) ), nifedipine and dacarbazine for unimolecular AB〖(1Φ)〗_(ε_(B≠0) ), and the stilbenoids group, axibinib and O-DAE for photoreversible AB (2Φ) reactions. The results obtained in this research show that the Φ-order kinetics approach offers a good description of the …
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Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… radio-and chemotherapy. Chemotherapy, using dacarbazine (DTIC), remains the standard treatment option. In melanoma, chemotherapy failure has partly been attributed to a resistant population which is endowed with higher clonogenic potential, and aberrant expression of membrane proteins known …
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TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… Administration (FDA) for metastatic melanoma: dacarbazine (DTIC) and interleukin-2 (IL-2). But even with these two drugs, fewer than 15% of patients have a favorable response and fewer than 5% of patients reach complete remission. On the other hand, the toxicity associated with DTIC and IL-2 is …