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Showing 1 to 2 of 2 for “"dUTPase"”.
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Estudo de modelagem molecular de derivados de desoxiuridina como inibidores da dUTPase de Plasmodium falciparum.
… deoxyuridine triphosphate nucleotidohydrolase (dUTPase) of Plasm odium falciparum (EC 3.6.1.23) was chosen as the molecular target for th is study. We produced a complete structural model of Pf dUTPase (PDB ID: 1VYQ) by homology modeling, since the crystal structure stored in the Protein Data …
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A Pharmacological Strategy Against African Sleeping Sickness
… is highly sought after. The essential enzyme, dUTPase, is an excellent drug target in the parasite while utilizing <em>S. cerevisiae </em>as a model system.</p> <p>dUTPase is essential in <em>T. brucei </em>(tbdUTPase), yeast (yDut1), and humans (hDUT). dUTPase being a dimer in <em>T. …