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Showing 1 to 10 of 10 for “"dGEMRIC"”.
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Quantification of blood Gd-DTPA levels : implications on dosing dGEMRIC
… magnetic resonance imaging of cartilage (dGEMRIC) is a novel technique that allows early diagnosis of osteoarthritis (OA). Under the current protocol, subjects are injected 0.2mmol of an MRI contrast agent (Gd-DTPA 2, Berlex Imaging, Wayne, NJ) per kilogram of body weight. Because the …
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Human studies evaluating dGEMRIC as a prognostic tool for knee osteoarthritis
… resonance imaging of cartilage, abbreviated dGEMRIC, can be used to estimate the GAG content of cartilage. A contrast medium is used, the concentration of which in the cartilage is inversely proportional to the amount of GAG. The purpose of this work was to evaluate dGEMRIC as a prognostic …
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Three-dimensional T1 quantification techniques for assessment of cartilage quality using dGEMRIC
… Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a previously presented method for identification of early OA using magnetic resonance imaging (MRI). By quantifying the T1 parameter in the cartilage after distribution of a contrast agent, a measure of the glycosaminoglycan (GAG) …
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In vivo Sub-regional dGEMRIC Analysis and Contrast Distribution in Clinical Studies of Human Knee Cartilage
… whether considering cartilage depth in vivo dGEMRIC would provide additional information on the molecular content and changes in normal and diseased cartilage. Methods: Study I was a longitudinal study on 23 healthy volunteers; Study II was a case-control study on 9 sedentary individuals and …
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Graphical interface for quantitative monitoring of 3D MRI data
… of medical interventions. In particular, the dGEMRIC technique has been used. Prior dGEMRIC data have been two-dimensional. Magnetic resonance equipment can currently produce three-dimensional dGEMRIC data, but software that analyzes three-dimensional data sets is lacking in practicality. This …
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Exploring issues for a cartilage degradation model
… that damage and repair can be observed by the dGEMRIC method of MR imaging. Primarily this included the iterative design of a cartilage tissue holder and testing of its ability to approximate uniaxial diffusion, as well as observation of glycosaminoglycan degradation induced by ADAMTS using …
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Spatially-localized correlation of MRI and mechanical stiffness to assess cartilage integrity in the human tibial plateau
… magnetic resonance imaging of cartilage (dGEMRIC), which measures the MRI parameter TI after equilibration with the ionic contrast agent Gd(DTPA)2-. With dGEMRIC, TlGd serves as an index of GAG content: we therefore examined whether cartilage stiffness could be related to dGEMRIC-measured …
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An investigation into the efficacy of MRI T2 in an OA population
… delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). In general, mean T2 in various regions of interest, normalized T2 as a function of distance from the bone, z score, comparison with dGEMRIC index, and threshold analysis were unable to differentiate between the level of OA or accurately …
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Knee Osteoarthritis: gagCEST MR Imaging of Articular Cartilage
… delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was made on twelve college football athletes who has been reported to have higher prevalence of cartilage lesions than the general population. gagCEST correlates well with dGEMRIC in evaluating relatively higher GAG concentrations. However, …
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Anterior Cruciate Ligament injury, Patient Variables, Outcomes and Knee Osteoarthritis
… delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) to estimate cartilage GAG content, as a proxy for cartilage integrity. Results indicated knee cartilage GAG changes 2 years after an ACL injury. Patients who had sustained a meniscectomy, or had a BMI > 25 kg/m2, had the most impaired …