Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"dFOXO"”.
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… The aims are the following: 1. Observe if dFOXO mutants affect temporal differentiation in the Drosophila eye. 2. Perform epistasis experiments to determine if dFOXO is downstream of other insulin signaling components. 3. Analyze the downstream targets of dFOXO that may play a role in …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… human <em>TBX20 </em>gene, interacts with <em>dFOXO </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle (IOB) formation. Previous studies have identified <em>mid</em>’s role in cell fate specification of sensory …
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The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
… fate, we found that mid collaborates with <em>dFOXO</em>. The <em>dFOXO</em> transcription factor is distinct in that it regulates cell proliferation and homeostasis within Insulin regulated stress induced pathway. The culmination of these studies suggests that Mid regulates cell fate …
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Insulin/IGF-like signalling and brain ageing in Drosophila melanogaster
… ageing and longevity. Overexpression of dPTEN or dFOXO (the antagonistic regulators of the IIS pathway), systemically or tissue-specifically, is reported to extend lifespan or delay specific tissue or organ ageing such as muscle and cardiac ageing. However, little is known about the role of IIS in …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… (<em>emc</em>)[8] and <em>dFOXO[10]</em>. In addition, the modENCODE consortium identified <em>bric-a-brac-1 </em>and <em>bric-a-brac-2 </em>(<em>bab-1</em> and <em>bab-2</em>) as theoretical <em>mid</em>-interacting genes that encode proteins harboring a BTB/POZ-ZF domain …