Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cytotoxicity activity"”.
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Design, synthesis and biological evaluation of novel tetra-substituted quinoline-3-carboxamides derivatives
… their biological activities against malaria and cytotoxicity. In achieving the objective, 2-chloroquinoline-3-carbaldehyde analogues 54A-G were synthesised from the reaction of acetanilides 53A-G and acetic acid. Knoevenagal reaction of 2chloroquinoline-3-carbaldehydes 54A-G with …
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Investigating the therapeutic effects of silver and gold nano particles capped with selected medicinal plants against tuberculosis
… liquid chromatography mass spectrometry (LC-MS). Cytotoxicity activity of plant extracts and nanoparticles were determined by MTS assay on HEK293 cells. The anti-inflammatory activity was determined through the nitric acid synthase (NOS) inhibitory test. The antimycobacterial activity was …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… with an R456T point mutation to compare their cytotoxicity activity towards cancer cells. Medical Biotechnology & Immunotherapy Research Unit Institute for Infectious Disease & Molecular Medicine South African Research Chair in Cancer Biotechnology ETA represents the wild type (wt) of …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… anti alcoholism drug has excellent anticancer activity against a wide range of cancers with its metal binding capability through its unique dithiol structure. Hence our group is interested in identifying clinically used dithiol compounds which are structurally similar to DS and has metal …
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The Biology of Mantle Cell Lymphoma: Exploring the Gender Difference in Mantle Cell Lymphoma
… the healthy controls exhibited greater cytotoxicity compared to the MCL patients. PBMCs were incubated with oestrone (female hormone in postmenopausal women), lenalidomide and IL-2 to further investigate the effects of these on the immune cells from male and female MCL patients. …
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Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves
… Therefore, the present study focuses on the activity guided purification of proteins from red maple leaves collected in spring and fall seasons. In addition, the focus of this project was in the evaluation of maple leaves employing bottom-up proteomics and De Novo protein profiling by PEAKS …
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… anticoagulant, anti-oxidant and cytotoxicity activity. The compound structures were confirmed through spectral nuclear magnetic resonance (NMR), mass (MS) and infrared (IR) spectroscopy data analysis. The antiplatelet aggregation activities of the compounds were evaluated against …
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The effects of snake venoms as cytotoxins on selected prostate cancer cell lines
… contortrix laticinctus were evaluated for cytotoxicity and selectivity in vitro against a panel of prostate cancer cell lines (DU145, PC3, LNCaP) and a non-malignant prostate epithelial cell line (PNT2A). The cytotoxicity activity of each venom was initially assessed using the SYTOX Green …
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Development Of Recombinant Immunotherapeutics for Triple-Negative Breast Cancer (TNBC)
… minimizing harm to healthy cells. This selective cytotoxicity would result in a significant improvement in TNBC treatment efficacy while reducing the side effects. The development of targeted anticancer therapies for TNBC is an active area of research and scientists are currently exploring various …