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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"cytotoxic activity"”.
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In vitro cytotoxic activity of equine lymphocytes on equine herpesvirus-1 infected allogenic fibroblasts
… a technique to analyze the <i>in vitro</i> cytotoxic activity of lymphocytes from adult horses against equine herpes virus-1 (EHV-1) infected allogenic equine dermal fibroblasts (EDF); 2) evaluate the ability of a 72 hour in vitro incubation with interleukin-2 (I L-2) to enhance the …
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Synthesis and mechanistic studies into the cytotoxic activity of garlic-related trisulfides in cancer cells
… to the synthesis of these compounds, their cytotoxicity and their mechanisms of action against cancer cells. Building on our group's previous research on the cytotoxicity of ajoene, which demonstrated its ability to modify proteins by S-thioallylation of cysteine residues through a …
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Proteomic Identification of Hemp (Cannabis sativa) Seeds by Tandem Mass Spectrometry and Evaluation of Cytotoxic Activity
… proteome. Further, investigations assessed the cytotoxic activity of hemp seed crude protein extract using MCF7 human breast cancer cell lines. The results showed that hemp crude protein extract inhibited the proliferation of MCF-7 cells in a dose-dependent manner. The IC<sub>50 </sub>value was …
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
… molecule extracts, leaving the protein’s bioactivity undiscovered. The present study demonstrated the antiproliferative activity of ajwain nsLTP1 in MCF-7, AsPC-1, and MCF10A cell lines and its structural stability in human serum and high-temperature conditions. The antiproliferative activity …
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Effects of low molecular weight compounds on growth, virulence gene expression and cytotoxic activity of Shiga toxin-producing Escherichia coli O157:H7
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Shiga toxin-producing Escherichia coli (STEC) infections are clinically associated with hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), and are the leading cause of acute renal failure in children. A …
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Phytochemical and pharmacological studies on some endemic Yucatecan medicinal plants
… resulting crude extracts were tested for their cytotoxic effect using the modified MTT (3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay followed by a bioassay-guided fractionation of the most active extracts in order to identify the active metabolites. The initial cytotoxic …
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Phytochemical investigation and biological activities of Sanicula europaea and Teucrium davaeanum. Isolation and identification of some constituents of Sanicula europaea and Teucrium davaeanum and evaluation of the antioxidant activity of ethanolic extracts of both plants and cytotoxic activity of some isolated compounds
… respectively. A study of the antioxidant activity of the 50 % ethanol extracts of S. europaea and T. davaeanum showed that on a mg/mg basis S. europaea and T. davaeanum have approximately 5%, 8 % antioxidant capacity of Trolox respectively. A study of the cytotoxic activity of davaeanuside …
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Untersuchungen zu Bacillus cereus Enterotoxin-Komplexen auf zellulärer Ebene
This paper deals with the in vitro activity of the B. cereus enterotoxin-complexes Hemolysin BL (HBL) and non-hemolytic enterotoxin (Nhe) on cells. For that purpose the cytotoxic and hemolytic activity of crude B. cereus culture supernatants was analyzed in cell culture assays and on blood agar …
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In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer
… and Sri Lanka had previously been shown to exert cytotoxic activity in the in vitro L1210 leukemic bioassay. For this thesis, these samples were screened for in vitro cytotoxic activity against the drug-sensitive breast tumor cell lines MCF-7, T-47D, ZR-75-1 and MDA-MB-231; the multidrug-resistant …
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Chemical and biological evaluation of palythoa tuberculosa collected from the red sea
… data. Palysterols B and G demonstrated cytotoxic activity on three human cancer cell lines (MCF-7, HeLa, and HT- 29). Palysterol G, in particular, was able to induce apoptosis in breast adenocarcinoma(MCF-7) cells
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The Isolation of Natural Products From Plant Extracts
… strain resulted in the isolation of the weakly cytotoxic biochanin A (an isoflavone compound). The bioassay of three mutant yeast strains (1138, 1104, and 1353) directed the isolation of DNA-damaging alkaloids from Solanum hostmannii. These alkaloids were identified as verazine and (20R) epimer …
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Intracellular Calcium and Protein Kinase C Regulate Nonspecific Cell-Mediated Cytotoxicity by Mouse Lymphocytes (Calmodulin)
… couplers in lymphocyte-mediated cytotoxicity was examined through the use of various pharmacological agents. The calcium ionophore A23187 caused a marked increase in nonspecific cytotoxicity by mouse spleen lymphocytes against SV3T3 target cells. Using a standard ('51)Cr-release …
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Characterization of Vaccinia Virus-Induced Cytotoxic Cells in the Syrian Hamster
… on noninduced and vaccinia virus-induced hamster cytotoxic cells was studied utilizing a murine monoclonal anti-mouse Thy 1.2 antiserum ((alpha)-Thy 1.2) which detects a Thy 1.2 homologue on hamster T cells. In the hamster, (alpha)-Thy 1.2 plus complement (C') killed 100 percent thymocytes, 60-80 …
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Compuestos emisivos de Pt(II) e Ir(III) con aplicaciones biológicas y en iluminación de estado sólido
… phosphines with carboxylic groups enhances the cytotoxic activity, probably associated with the inhibition of tubulin microtubules. On the other hand, the work also present the synthesis of cationic complexes of stoichiometry [Ir(C^N)2(N^N)]+, which has been especially designed for their use in …
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Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism
… the current regime. The development of novel cytotoxic platinum based compounds, both trans- and polynuclear, provides for the promising treatment of clinical platinum drug resistant tumors. While the cytotoxic activity of platinum drugs provides for a hopeful outlook, the ultimate factors …
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Studio di complessi di rame (II) e platino (II) con proprietà antitumorali
… of new metal complexes with increased activity and lower side-effects. Besides, the use of drug combinations with synergistic effect, i.e. an effect greater than the sum of the effects of the single drugs, has been introduced. This thesis is focused on the preparation of Cu(II) and …
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Applications of the achmatowicz rearrangement in natural product synthesis
… of DNA and RNA synthesis and have potent cytotoxic activity in vivo. The Ajudazols A and B were isolated in 2004 and have antifungal activity against several important food spoilers. The work that follows details the design and development of a novel method for the generation of the …
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In Vitro tests for immunomodulatory effects of medicinal plants used in the treatment of Malaria in South Africa
… of malaria were collected and evaluated for cytotoxic and lymphocyte-proliferating effects. These included Acokanthera oppositofolia, Zanthoxylum capense, Glycyrrhiza glabra, Harpephyllum caffrum, Lippia javanica, Pentanisia prunneloides, Psidium guajava, Typha capensis and Cannabis sativa. …
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Cellular responses against DNA damaged by platinum anticancer drugs
The anticancer activity of platinum-based drugs such as cisplatin, carboplatin, and oxaliplatin is mediated by their ability to attack DNA such that generated adducts trigger numerous cellular responses. A better understanding of these processes is critical for developing more effective therapeutic …
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The effects of snake venoms as cytotoxins on selected prostate cancer cell lines
… contortrix laticinctus were evaluated for cytotoxicity and selectivity in vitro against a panel of prostate cancer cell lines (DU145, PC3, LNCaP) and a non-malignant prostate epithelial cell line (PNT2A). The cytotoxicity activity of each venom was initially assessed using the SYTOX Green …
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