Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"cytotoxic T lymphocytes (CTL)"”.
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Characterization of a T cell receptor and its ligands
Cytotoxic T lymphocytes (CTL) recognize and lyse cells presenting viral or tumor-associated antigens associated with class I major histocompatibility complex proteins. Recognition occurs between the T cell receptor (TCR) and a complex of an antigenic peptide/major histocompatibility complex (MHC) …
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How TCR signal strength controls CTL polarisation for target killing
Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
<p>Cytotoxic T-lymphocytes (CTL) can lyse infected or transformed cells through recognition of peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid …
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Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof
… and minimal IgG1 production. A colorimetric cytotoxic T lymphocytes (CTL) assay was developed to demonstrate that strain RB51 induced an antigen-specific CTL reaction that probably plays an important role in protection. The results suggest that optimal protection against brucellosis requires …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the …
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The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
… tolerance to self and for the regulation of cytotoxic T lymphocytes (CTL)-mediated adaptive immune responses against pathogens and cancer cells. Interestingly, several findings have suggested that the cytoplasmic tail of MHC class I plays a functional role in the regulation of CTL immune …
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From Naturally Occurring Tumor Immunity to Supernatural T Cells: Isolation and Characterization of a Murine T Cell Receptor Specific for Human Breast and Ovarian Tumor Antigen Cdr2
… cancer. We previously demonstrated cdr2-specific cytotoxic T lymphocytes (CTL) in the peripheral blood of HLA-A2.1+ PCD patients, suggesting that CTLs mediate tumor immunity in these patients. Cdr2 is expressed by a large proportion of breast and ovarian tumors from individuals who do not develop …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
<p>CD8<sup>+</sup> cytotoxic T lymphocytes (CTL) frequently infiltrate tumors, yet most melanoma patients fail to undergo tumor regression. We studied the differentiation of the CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… viruses, such as HBV and HCV, are not directly cytopathic; instead liver injury is due to a vigorous immune response. Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells kill virally infected and malignant cells by two major pathways, the perforin/granzyme pathway and the Fas and/or …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… to cancer is dependent on functionally efficient cytotoxic T lymphocytes (CTL). Checkpoint inhibition therapy is aimed at reinvigorating local cytotoxic T cells, however the rate of immunotherapy failure in non-small cell lung cancer (NSCLC) is as high as 80%. An improved mechanistic understanding …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
T lymphocytes are critical components of an effective adaptive immune response, with different subsets performing proinflammatory and immuno-suppressive roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. …
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Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer
Cytotoxic T Lymphocytes (CTL) are cells of the adaptive immune system that are responsible for the elimination of virally infected, tumorigenic or damaged cells through mechanisms that induce target cell lysis. The aim of this project was to identify genes that can impact CTL lytic capacity, using …