Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"cytotoxic T lymphocytes"”.
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Generating memory cytotoxic T lymphocytes through repetitive peptide boosting
Cytotoxic T lymphocytes (CTLs) play a critical role in controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. However, generating memory CTLs remains a major challenge for conventional …
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Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma
Cytotoxic T lymphocytes (CTLs) are key effectors in antitumour immunity, patrolling tissues to detect and destroy cancerous cells by directing cytotoxic granules toward the immunological synapse formed with their target. Although CTL infiltration into solid tumours often correlates with improved …
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
… transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is a powerful immunosuppressant used in the clinic in the context of organ transplantation. However, not much is known about the full extent of the role of mTOR …
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Naturally occuring peptides recognized by cytotoxic T lymphocytes (CTS) : peptide abundance as a determinant of CTL function
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Characterization of a T cell receptor and its ligands
Cytotoxic T lymphocytes (CTL) recognize and lyse cells presenting viral or tumor-associated antigens associated with class I major histocompatibility complex proteins. Recognition occurs between the T cell receptor (TCR) and a complex of an antigenic peptide/major histocompatibility complex (MHC) …
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A Single Cell Approach to TCR Signal Strength
Cytotoxic T lymphocytes (CTLs) play a key role in the cell-mediated immune response against virally-infected and tumourigenic cells, killing their targets through the release of cytolytic granules. T cell receptor (TCR) recognition of foreign peptides presented by Class I MHC molecules stimulates …
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Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells
Two important mechanisms of lymphocyte-mediated cytotoxicity, one perforin based and the other Fas ligand (FasL) based, have been characterized recently. It has also been shown that CD44, an adhesion molecule, can participate in signaling cytotoxic activity of cytotoxic T lymphocytes (CTLs). In the …
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How TCR signal strength controls CTL polarisation for target killing
Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide …
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Conserved Non-Pocket Interactions Drive The Diversity of Peptide Presentation By Mhc Class I Molecules
<p>Cytotoxic T-lymphocytes (CTL) can lyse infected or transformed cells through recognition of peptides presented on human leukocyte antigen (HLA) molecules. A thorough understanding of peptide-HLA interactions is needed for improvement of CTL-based immunotherapies. We observed that aspartic acid …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
CD8+ cytotoxic T lymphocytes (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present study, we demonstrate that monoclonal antibody (mAb) 9F3, directed against murine CD44 expressed on cytotoxic T lymphocytes (CTls), can trigger the …
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Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof
… and minimal IgG1 production. A colorimetric cytotoxic T lymphocytes (CTL) assay was developed to demonstrate that strain RB51 induced an antigen-specific CTL reaction that probably plays an important role in protection. The results suggest that optimal protection against brucellosis requires …
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The immunomodulatory properties of AZT used in the treatment of AIDS
… Also, AZT inhibited the generation of cytotoxic T lymphocytes when added to the culture and this inhibition was reconstituted by the addition of exogenous IL-2. Together, our studies demonstrate that AZT modulates the phenotype and function of cells of the immune system which, in turn, …
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Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
… of secretory granules from immune cells such as cytotoxic T-lymphocytes, natural killer cells and mast cells play crucial physiological roles in protecting individuals from pathogens. The exocytosis is known to be mediated by Soluble N-ethylmaleimide sensitive factor Attachment protein REceptor …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
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Cellular Uptake of Neutrohpil Elastase Links Inflammation to Adaptive Immunity
… susceptibility to lysis by CCNE-specific cytotoxic T lymphocytes. We also show that after taking up NE and proteinase 3 (PR3), a second primary granule protease with significant homology to NE, breast cancer cells cross-present the NE- and PR3-derived peptide PR1 rendering them susceptible …
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Components of the Membrane Attack Complex (Mac) of Human Complement: Functional Studies of Their Macpf Domains
… a self-polymerizing protein released from cytotoxic T- lymphocytes.</p> <p>The first aim was to express and characterize MACPF domains of C6 and C7. Based on sequence homology in the MACPF domains of MAC family proteins, it was hypothesized that the MACPF domains of C6 and C7 may hold …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the …
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