Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"cytotoxic T cells"”.
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Signal transduction of transforming growth factor-Beta in cytotoxic T cells
Transforming-Growth-Factor-beta1 (TGF-b1) ist ein multifunktionelles Zytokin, welches insbesondere Zellwachstum und Zelldifferenzierung koordiniert. TGF-b ist vor allem dafür bekannt, Zellen des Immunsystems zu beeinflussen. TGF-b steuert zum Beispiel die Differenzierung von T-Zellen und und deren …
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Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix
Cytotoxic lymphocytes (CTLs) traffic through tissues in search of antigen and mount protective immune responses against viral infections and cancer. While molecular mechanisms of CTL antiviral effector functions have been established in vitro, they have been defined in the absence of physiological …
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The role of calcium in the destruction of target cells by cytotoxic T cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Harvard-MIT Divison of Health Sciences and Technology Program in Medical Engineering and Medical Physics, 1987.
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A Single Cell Approach to TCR Signal Strength
Cytotoxic T lymphocytes (CTLs) play a key role in the cell-mediated immune response against virally-infected and tumourigenic cells, killing their targets through the release of cytolytic granules. T cell receptor (TCR) recognition of foreign peptides presented by Class I MHC molecules stimulates …
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Caffeine Supplementation and Moderate Intensity Exercise Modulates the Cytotoxic Lymphocyte Subset (CD+8) in NaIve and Tolerant Individuals
… CX3CR1 to determine cell migration, CD4=helper T cells, CD8=cytotoxic T cells, CD19=B cells). Blood was analyzed using flow cytometry. We found that cytotoxic T cells showed significant increases following the caffeinated run in both groups combined (tolerant and naïve, p=0.001) and specifically …
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The regulation of CD8+ T cells by nutrient availability
… regulation and function of autophagy as CD8 T cells encounter amino acid deprived conditions. The study also examined the role of the AMP dependent kinase in CD8+ T cell responses to metabolic stress. To study autophagy a novel fluorescent autophagy reporter mouse model was used that allowed …
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Identification and characterisation of a novel gene, DWNN, isolated from promoter-trapped Chinese hamster ovary cells
The process of cytotoxic T lymphocyte (CTL) killing involves the recognition and destruction of foreign antigens by cytotoxic T cells and is of crucial importance to the defence of the organism against viral infections. Defects in this process can lead to various autoimmune diseases and cancer. The …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… within breast tumors correlate to an increase in cytotoxic T Cells, T cell effector enzymes (Prf-1 and Gzmb), and improved survival rates. Importantly, our in vitro studies suggest that ABCA1 influences several functions of macrophages relevant to tumor biology. Specifically, ABCA1 shifts …
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Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells
… in the immune system notably in effector Th17 cells where it seems to be critical for the production of the IL-22 cytokine. It is known that AhR ligands such as dioxins can suppress CD8 T cell mediated antiviral immune responses but it is not known whether this reflects a direct role of the AhR …
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Development of a novel antibody molecule for redirected T cell immunity to tumor cells: The bispecific single chain antibody
… bind them allow the specific targeting of cancer cells. A promising use for these anti-tumor antibodies involves redirecting a patient's own cytotoxic T cells (CTL) to specifically kill tumor cells by the use of a bispecific antibody. This approach is achieved through the use of bispecific …
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A Numerical Study of a Delay Differential Equation Model for Breast Cancer
… immune response to the growth of breast cancer cells and investigate the impact of certain drug therapies on the cancer. We use delay differential equations to model the interaction of breast cancer cells with the immune system. The new model is constructed by combining two previous models. The …
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Roles For Braf Kinase Activating Mutations In Melanoma: Microenvironmental Immunosuppression
… kinase pathway. This genetic lesion endows tumor cells with proliferative and survival advantages, and metastatic melanoma patients treated with the BRAF(V600E)-specific inhibitor, Vemurafenib, have shown dramatic clinical responses. Here, I show that BRAF(V600E) induces transcription of the IL-1α …
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Cancer immunotherapy with Mucin-1 and cytokines
… of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, and ovary making an ideal target for …
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The role of nonclassical MHC class I products in the development and function of CD8+ T cells
… present pathogen-derived peptides to CD8+ cytotoxic T cells. This interaction mediates the detection and clearance of intracellular infections. Emphasis has been placed on the critical role of classical class I MHC products in the development and function of CD8+ T cells. In this thesis, I …
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Novel strategies for characterizing T Cell responses in SIV-infected rhesus monkeys
… growing. HIV infects and depletes CD4+ helper T cells, affecting the ability of the immune system to defend the host against common infections. While anti-retroviral therapy has decreased morbidity and mortality, these drugs are not curative. In addition, they are beyond the financial reach of …
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Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools
… immunotherapy is the generation of high avidity cytotoxic T cells which can recognise and respond to very low concentration of antigens. This sensitivity of T cells is usually determined by peptide titration ELISpot assays. Even though these assays are generally useful, they are laborious and …
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Immunotherapy in multiple myeloma
… these DC are capable of inducing anti-MM cytotoxic T cells, which exhibit considerable anti-MM cytolytic activity. However, the DC from MM patients still display abnormal chemokine receptor expression, which may inhibit their capability to migrate to lymph nodes in-vivo in order to …
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Engineering Proteins Encoded by the Major Histocompatability Complex
… by a receptor (T cell receptor, TCR) on cytotoxic T cells (CTL) stimulating the release of various proteins, including enzymes, that destroy the infected cells. The dynamic interactions between TCRs and peptide-MHC class I complexes have been studied extensively at the molecular level by …
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Cellular and viral factors affecting HIV-1 silencing and reactivation
… virus from an infected individual is a pool of cells infected with transcriptionally silent proviruses. A key pillar of the strategy to eradicate latent viruses has been called ‘kick and kill’, whereby the latent virus is stimulated to transcribe rendering the host cell vulnerable to eradication …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the …
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