Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"cytotoxic T cell"”.
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Dendritic cell dysfunction restrains cytotoxic T cell responses against cancer
… are often characterized by the presence of a T cell infiltrate in tumors. However, T cell infiltration does not always correspond to ICB efficacy. Tumor-reactive T cells can acquire persistent dysfunctional states, which are resistant to ICB reinvigoration. Increasing evidence suggests that T …
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Cytotoxic T cell function in solid tumors: principles and implications for immunotherapy
Contains fulltext : 145309.pdf (Publisher’s version ) (Open Access)
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The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Function and Metabolism
… how CRF impacts the function of specific immune cells such as cytotoxic CD8+ T cells (Tc). Tc utilize cytokines, such as interferon-γ (IFN-γ), to orchestrate cell mediated responses to viral infections and tumors (1). Production of cytokines is energy and resource intensive, necessitating …
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Identifying regulators of cytotoxic T cell function through molecular and genetic screening
Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the …
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Human macrophage model for selective evaluation of CD8⁺ and γδ⁺ cytotoxic T cell function in tuberculosis
The human macrophage cell line U937 was investigated as an in vitro model for human macrophage function in mycobacterial infections. This involved evaluating the ability of differentiated U937 cells to phagocytose Mycobacterium tuberculosis, control intracellular mycobacterial growth, and present …
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Role of Multiple Toll-Like Receptor Activation in Regulating Cytotoxic T Cell Priming to Lympocytic Choriomeningitis Virus Infections
… receptors (TLR), present on various immune cells such as professional antigen-presenting cells (pAPCs). On recognition of its ligand, these receptors activate pAPCs, which may in turn influence naïve CD8+ T cell activation and affect their abilities to clear viral infection. However, how TLR …
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CD8⁺ T Cell Response to Influenza Virus
… effectively dispatched by the immune system. The cell-mediated lysis of infected cells is a particularly important step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to …
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Correlates of risk of TB disease in infants with differential response to BCG vaccination
… Th1/Th17 cytokine production by BCG-specific T cells, release of pro- and anti-inflammatory mediators, cytotoxic T cell potential and proliferation in response to BCG as potential correlates of risk of TB disease but none of these outcomes were different between cases and controls. However, …
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Phenotypic characterization of stress Leukocytosis
… research that characterizes the mobilization of cytotoxic T cell subsets and monocyte populations in response to acute psychological stress and β-agonist (isoproterenol) infusion. Chapter two showed that γδ T cells are mobilized in response to psychological stress and isoproterenol infusion, …
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Cross-Presentation Is A Source of Tumor Antigens For Multiple Myeloma Immunotherapy
… of the immune system where antigen presenting cells (APCs) prime cytotoxic T cell responses. We have recently identified cross-presentation as a mechanism by which solid tumors present exogenous antigens. We therefore hypothesized that multiple myeloma would be capable of cross-presentation as …
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… functions of FOXP3+ T regulatory cells (Tregs) and EOMES+ type 1 regulatory T (Tr1) cells, which produce the anti-inflammatory cytokine IL-10, have been identified as key modulators of anti-tumor immunity. IL-10 plays a dual role in cancer, functioning as a checkpoint receptor …
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Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer
Checkpoint immunotherapy unleashes T cell antitumor potential which has revolutionized cancer treatment showing unprecedented long-term responses. However, most patients do not respond to immunotherapy which often correlates with a dysfunctional or immunosuppressive myeloid compartment. …
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Immunotherapy in multiple myeloma
… allowed reliable measurement of dendritic cell (DC) subsets and B cell numbers in the blood of normal subjects, and patients with MM throughout the disease course. The numbers of blood myeloid DC (BmDC) and blood plasmacytoid DC (BpDC) are low throughout the course of the disease, and only …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… accelerating the growth and migration of IBC cells. Intriguingly, CIBERSORT deconvolution showed that high AXL expression is correlated with an immunosuppressive TME, including the larger population of M2 macrophages, in tumor tissues from patients with IBC.</p> <p>Next, to enhance the …
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Induction of myosin cross-reactive antibody and cytolytic T cell responses in mice with Streptococcus pyogenes
… not adult, mice to mount a myosin-reactive CD8+ cytotoxic T cell response following immunization with S. pyogenes. Our observations indicate that the response is additionally dependent on the genetic background of mice, the route of immunization, and requires M protein.;In summation, our results …
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The effect of manipulating apoptotic cell uptake on their immunogenicity
… system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours. Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially inflammatory or …
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The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
… cytokine and growth factor sensing in T cells and controls transcriptional programs that determine CD8+ cytotoxic T cell fate and trafficking. mTORC1 is inhibited by the drug rapamycin which is a powerful immunosuppressant used in the clinic in the context of organ transplantation. …
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OAdV7, an ovine adenoviral vector as a novel vaccine vector for tumour immunotherapy
… with the ability to efficiently transduce human cells and activate the innate immune system, making them one of the most popular viral vectors for vaccine development. To date, the majority of the studies in the literature have focused upon human adenovirus serotype 5 (HAdV5) for the development …
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Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy
… the essential role in activating and expanding T cell responses to antigens, cytokines are comprehensively studied for cancer therapy. The efficacy of cancer immunotherapy is diminished by the fact that spontaneous tumors often downregulate antigen expression and/or presentation. The density of …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… as the new standard of care for advanced clear cell Renal Cell Carcinoma (ccRCC), the deadliest urological malignancy. However, both efficacy and toxicity of immunotherapies is highly patient-specific and difficult to predict. This underscores the need for robust preclinical models of …
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