Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"cytostatic"”.
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Specific, Reversible Cytostatic Protection of Normal Cells Against Negative Effects of Chemotherapy
Chemotherapy is a common and effective method to treat many forms of cancer. However, treatment of cancer with chemotherapy has severe side effects which often limit the doses of therapy administered. Because some cancer chemotherapeutics target proliferating cells and tissues, all dividing cells, …
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Novel Phase I/II Designs for Cytotoxic and Cytostatic Agents, and Combination Treatments
… while safeguarding patient safety. Second, for cytostatic agents with non-monotonic dose-efficacy relationships, a model-assisted design—STEIN-NETS—is proposed. By integrating NETS and continuous efficacy, it improves robustness and efficiency in trials where efficacy does not increase linearly …
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Depletion of Treg cells for potentiation of cancer treatment with HPMA copolymer-bound cytostatic drug conjugates"
Nádorová onemocnění představují závažný celosvětový problém, přičemž incidence jejich výskytu stále narůstá. Jelikož podávání řady běžně užívaných protinádorových terapeutik způsobuje vážné vedlejší účinky, je věnována velká pozornost tvorbě nových šetrnějších léčebných postupů. Cílem této práce …
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Characterization of a new miniaturized hollow-fiber bioreactor for cultivation of cell lines and primary cells to improve cytostatic drug testing in vitro
… in the bioreactor by light-microscopy. The cytostatic drug Ara-C shows a dose-dependent growth inhibition of HL-60 cells and a dose-response curve similar to controls in culture plates. The bioreactor system is highly flexible since several systems can be run in parallel, soluble drugs can …
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ΕΠΙΔΡΑΣΗ ΤΩΝ ΙΟΝΤΩΝ ΡΟΔΙΟΥ ΣΤΟ ΓΕΝΕΤΙΚΟ ΥΛΙΚΟ ΚΥΤΤΑΡΩΝ ΤΟΥ ΘΗΛΑΣΤΙΚΟΥ CHINESE HAMSTER "ΚΡΙΚΗΤΟΣ ΟΦ ΑΡΓΥΡΟΧΡΟΟΣ"
… IN VITRO, IN A MAMMALIAN CELL LINE (CHV79) AS CYTOSTATIC/MUTAGENIC AGENT AS WELL AS ITS POSSIBLE MECHANISM OF ACTION. ALL THE RESULTS INDICATE A TRANSIENT CYTOSTATIC ACTION DUE AN INTERACTION OFRHODIUM COMPLEX WITH THE DNA MACROMOLECULE. THIS TRANSIENT ACTION MAY DUE EITHER TO A REPAIRABLE …
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Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΑΣΙΤΙΑΣ, ΠΡΩΤΕΙΝΙΚΗΣ ΔΥΣΘΡΕΨΙΑΣ, ΚΥΤΤΑΡΟΣΤΑΤΙΚΩΝ ΚΑΙ ΑΝΤΙΒΙΟΤΙΚΩΝ, ΣΤΗΝ ΑΚΕΡΑΙΟΤΗΤΑ ΤΟΥ ΒΛΕΝΝΟΓΟΝΙΟΥ ΕΝΤΕΡΙΚΟΥ ΦΡΑΓΜΟΥ. (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ)
… PROTEIN MALNUTRITION, ANTIBIOTICS AND CYTOSTATICS ON THE GASTROINTESTINAL MUCOSAL BARRIER. EACH FACTOR WAS EXAMINED EITHER ALONE OR INCOMBINATION. WE STUDIED THE BACTERIAL TRANSLOCATION FROM THE INTESTINAL LUMEN TO MESENTERIC LYMPH NODES, LIVER, SPLEEN, KIDNEY AND LUNGS, BY CULTURING …
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A novel nanodelivery system for combination tumor therapy
… tumor regression in the clinic due to both the cytostatic nature of anti-angiogenic therapy and the potential formation of new regions of hypoxia within the tumor after therapy. The new therapeutic paradigm is for combining both anti-angiogenics and traditional cytotoxic agents for a synergistic …
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The Role and Mechanism of The Homeobox Gene Dlx4 In Transforming Growth Factor-B Resistance In Cancer
… TGF-b inhibits cell growth by controlling a cytostatic program that includes activation of the cyclin-dependent kinase inhibitors p15<sup>Ink4B</sup> and p21<sup>WAF1/Cip1</sup> and repression of c-myc. In contrast to normal cells, many tumors are resistant to the anti-proliferative effect of …
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ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ
… ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, …
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Exploring the in vitro effects of chronic methamphetamine exposure on selected cancer cell lines
… at all time points. Instead, METH produced cytostatic modulation varied by cell line and concentration. All lines exhibited delayed mitochondrial hyperactivity, suggesting potential metabolic compensation in response to sustained stress. ROS measurements revealed oscillatory redox dynamics, …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… overexpression of 14-3-3ζ inhibits TGF-β’s cell cytostatic program through destabilizing p53 in non-transformed human mammary epithelial cells. Mechanistically, we found that 14-3-3ζ overexpression leads to 14-3-3σ downregulation, thereby activates PI3K/Akt signaling pathway and degrades p53, and …
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From bench to bedside : elucidating vestibular schwannoma pathobiology to devise effective pharmacotherapies
… inhibition, achieved through salicylates, was cytostatic against primary VS cells. Our in vitro findings are in line with our retrospective findings that VS patients taking aspirin demonstrate halted tumor growth. Anti-inflammatory drugs such as aspirin could be efficacious against VS. …
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Brønsted acid-catalyzed alkylation of tetrazoles with alcohols
… antimicrobial, antiviral, antiallergic, cytostatic and nootropic biological activities. Traditionally, tetrazoles have been alkylated using alkyl halides under basic conditions. However, alcohols are the most convenient alkylating reagents. While Lewis and Brønsted acid-catalyzed …
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Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
… for therapies even if treatment goals are purely cytostatic. One particular therapeutic strategy is the metronomic (continuous and low) dosing of conventional chemotherapy. There is evidence to suggest that tumour vasculature is the main target of this dosing schedule resulting in an overall ‘non …
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… Title of diploma thesis: Study of modulation of cytostatic resistance using selected targeted anticancer drugs Cancer diseases rank among the most common causes of death, with increasing prevalence and incidence. The effectiveness of anticancer therapy is often diminished by multidrug resistance …
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Design, Chemical Synthesis and Biological Evaluation of Potential New Antiviral Agents
… the antiviral activity must be related to cytostatic effect, in order to select the ones with a favored selectivity index. Unfortunately, the molecules showed paragonable values in antiviral and cytostatic effects, the latter one not easily predictable neither by the chemical structure, nor …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
… cancer cell lines which remain sensitive to the cytostatic effect of TGFβ, we found that LPA up-regulated expression of the cyclin-dependent kinase inhibitor p21Waf1. But this up-regulation was not observed in TGFβ-resistant ones. We examined the possibility that LPA-induced p21 might contribute …
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Centralised Preparation of Medicinal Products for Systemic Treatment of Malignant Diseases in Hospital Pharmacies in Bulgaria – Specifics, Challenges and Prospects // Централизирано разтваряне на лекарствени продукти за системно лечение на злокачествени заболявания в болничните аптеки в България – специфики, предизвикателства и перспективи
… with the regulations. - The value of unused cytostatic residues reimbursed by the NHIF is increasing annually, with the trend being a decrease in active units and an increase in value. - Pharmacists preparing solutions are mainly female master pharmacists, aged 36-50, most of whom have …
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Entwicklung eines Hepatozytenbioreaktors zur Anwendung in der Toxikologie und Metabolismusforschung
… were set to 100%. Cyclophosphamide (CYCL), whose cytostatic effect is dependent on CYP 450 biotransformation was used as a model substrate. CYCL showed decrease of EAR in hepatocytes, but not in ZR 751 cells. Bioreactor supernatant including CYCL was pumped into the microphysiometer and EARs of …
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Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination
… Since chemotherapeutic treatments have potent cytostatic effects, we posited they enhance T cell dysfunctionality; which leads to limited therapeutic efficacy. Paclitaxel is a potent chemotherapeutic agent currently being administered in Stage III clinical trials; however, it reduces T cell …
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