Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"cytosolic pH"”.
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The production of 4-adminobutyrate in response to treatments reducing cytosolic pH and the regulation of intracellular pH
… H+ consumption are parts of a metabolic pH-stat mechanism which ameliorates the intracellular pH decline associated with anaerobiosis or other treatments. To test this hypothesis GABA production and efflux have been measured in isolated Asparagus sprengeri cells in response to three …
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The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
… whose positive charge changes depending on pH, rather than the lysines or arginines, commonly found in classical bipartite NLSs, suggesting the possible ‘pH-dependency’ of this NLS. Indeed, decreasing the cytosolic pH either with nigericin, a Na+/H+ exchanger or low pH KRB (pH=6.5) buffer …
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Characterization of The Ato Gene Family In Alternative Carbon Metabolism
… of immunocompromised individuals. Macrophages are important innate immune cells that limit the niches in the human body in which <em>C. albicans </em>can persist through phagocytic removal. However, following phagocytosis <em>C. albicans</em> readily escapes from the immune cell by …
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Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains
… dermonecrotic AB-type toxin that causes atrophic rhinitis, and homologous domains in other toxins. We address both the N-terminal domain necessary for receptor-mediated endocytosis into the cell, as well as the intracellular membrane localization domain (MLD), which is believed to be …
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The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication
… domain. While M2, CM2, and MCM could all alter cytosolic pH to varying degrees when expressed from cDNA, only M2 and MCM could at least partially complement an M2-null virus in a trans-complementation system. This data suggests that while the CM2 ion channel activity is similar to that of M2, …
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Exp1p is a cargo adaptor for Sec24p mediated export the plasma membrane H+̳ ATPase from the ER in S. cerevisiae
… required for nutrient uptake and maintenance of cytosolic pH and accounts for ~25% of the total plasma membrane proteins. We previously reported that Pmalp requires the Sec24p paralog Lstlp for efficient export from the ER. Here we report the identification of a novel gene, EXP1 (E̲R ex̲port of …
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Die ß-Untereinheit minK verändert die Reaktion des menschlichen Kaliumkanals KvLQT1 auf Änderungen des zytosolischen pH, seine Temperaturempfindlichkeit und seine Empfindlichkeit für Pharmaka
… führt sowohl zu Veränderungen der biophysikalischen Eigenschaften, wie der Spannungsabhängigkeit und der Aktivierungskinetik des Stromes, als auch zu einer unterschiedlichen Empfindlichkeit für Pharmaka. So zeigt IKs eine höhere Empfindlichkeit als IKv für die Hemmstoffe 293B, Azimilid …
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Normoxic and anoxic metabolism of Nicotiana tabacum transformants lacking root nitrate reductase
… survival of hypoxic and anoxic (flooding)-phases. For that purpose, we compared the response of roots of hydroponically grown tobacco wildtype (Nicotiana tabacum cv. Gatersleben) and of a transformant (LNR-H) with no nitrate reductase (NR) in the roots but almost normal NR in leaves (based …
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Ca2+ signalling between the endoplasmic reticulum and lysosomes
… temporal dynamics of Ca2+ signals. Increases in cytosolic free Ca2+ concentration ([Ca2+]c) are due to influx from either an infinite extracellular Ca2+ pool or from the more limited intracellular Ca2+ stores. Stimulation of the endogenous muscarinic (M3) receptors of human embryonic kidney (HEK) …