Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"cytoskeletal proteins"”.
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Organization and expression of genes encoding cytoskeletal proteins in Plasmodium falciparum
Contains fulltext : mmubn000001_083349839.pdf (Publisher’s version ) (Open Access)
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
… Specifically, we investigate the role of cytoskeletal proteins on resisting mesenchymal stem cell deformation. An improved understanding of the relative contributions of microfilaments and microtubules to cell deformation characteristics will aid in the interpretation of cellular …
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Analyzing GFP-tagged cytoskeletal protein colocalization in human carcinoma cells
Cytoskeletal proteins function as dynamic, complex components involved in cellular structure and signaling. Characterizing the roles of such proteins would greatly benefit many research areas, including the study of cancer and protein-related diseases. There is currently no accurate, high …
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Analysis of the effects of BrdU on DLKP human lung cancer cells by two-dimensional difference gel electrophoresis and mass spectrometry
… (DLKP) resulted in increased expression of the cytoskeletal proteins Keratin 8 and 18 and the cell adhesion proteins a2 and b1 integrin. This study investigated protein expression changes in differentiating DLKP cells following exposure to 10yM BrdU. DLKP cells were grown in culture flasks and …
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Immunological investigations into synaptic plasticity
… changes in the chick brain using antisera to the cytoskeletal proteins (Xtubulin and microtubule-associated protein 2 following passive avoidance training and 3) using antibodies to synaptically-enriched antigens to map time- and locus-specific changes in hippocampal subfields following long-term …
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Defining the human endothelial transcriptome
… genes is enriched in nucleic acid binding proteins, cytoskeletal proteins and isomerases as well as certain known markers of endothelium, and the complete list of genes can be found at ... We have also studied the effect of a 4-hour exposure of HUVEC to 10 U/mL of IL-1, and detected 491 …
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Analysis of protein-protein interactions linked to the formation of a bacterial cytoskeleton in Mycoplasma pneumoniae
… As gene products of the hmw2 gene (MPN310), two proteins were identified, the full-length protein HMW2 with a molar mass of 216 kDa and a smaller one (HMW2-s) with only 25 kDa. HMW2-s was considered to be the processing product of HMW2, but it could be shown by determining the N-terminus of …
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Molecular mechanisms of radial axonal growth : insights from analysis of neurofilament gene-targeted mice
… that wraps around the axon and the expression of proteins known as neurofilaments (NFs) within the axon. NFs are cytoskeletal proteins composed of neurofilament light (NF-L), medium (NF-M) and heavy (NF-H) subunits. It was not well understood how NF subunits mediate the radial growth of axons. To …
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Telomerase a prognostic marker an therapeutic target
… activity resulted in down regulation of various cytoskeletal proteins with correlative evidence of the involvement of telomerase in regulating the expression of vimentin. Vimentin plays an important role in tumour metastasis and is used as an indicator of glioma metastasis. Inhibition of …
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Investigating a novel Asgard archaeon and its tubulin-like proteins
… encodes many Eukaryotic Signature Proteins (ESPs); proteins that were once thought to be unique but ubiquitous to eukaryotic cells. The presence of ESPs in the Asgard Archaea has challenged the definition of a eukaryote, suggesting that certain ‘eukaryotic-specific’ systems, such as …
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Obscurin Mediates Ankyrin Complex Formation In The Heart
… cell adhesion molecules, and contractile proteins are crucial to cardiac function. Interactions between adaptor proteins such as ankyrins and cytoskeletal proteins such as obscurin play a pivotal role in organizing these functional domains in cardiomyocytes. Therefore, dysfunction of both …
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Factors influencing the responsiveness of human bronchi
… cascades and assembly of contractile and cytoskeletal proteins. Furthermore, airways function is also regulated by a number of key airway, lung and teleological events that collectively determine the bronchial tone. Therefore, the aim of this thesis was to investigate a number of factors …
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Identification of altered Ras signaling and intermediate filament hyperphosphorylation in giant axonal neuropathy
… GAN patients develop an abnormal organization of cytoskeletal proteins called intermediate filaments (IFs), which normally provide strength and support for the overall cell structure. The irregular IF structure in GAN patient neurons leads to a progressive loss of motor skills in children and …
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The streptomyces cytoskeletal protein (Scy) is a key component of the tip organising centre for polarized growth in streptomyces coelicolor
… that bacteria have a number of eukaryotic cytoskeletal homologues as well as a number of accessory proteins unique to prokaryotes. As cell shape determination is dependent on the sites of insertion of new cell wall material, this is characteristically organised and driven by cytoskeletal …
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Membrane-cytoskeleton associations during myogenesis
… associations involving specific membrane proteins were studied in developing L8E63 cells on the basis of the following criteria: Triton-insolubility, co-localization and co-extraction with cytoskeletal proteins, and sensitivity to cytoskeleton-directed drugs. The cell surface dynamics of …
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Localization of Cytoskeletal Elements in Teleost Retinal Pigment Epithelium
The G.3.5 antigen (Mr = 100,000) has been localized in brain, cerebellum, skeletal, cardiac, and smooth muscle tissues using the G.3.5 mAb, and has been described as an IFAP on the basis of its co-localization and co-isolation with desmin. Through biochemical analysis, the G.3.5 antigen was found …
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Structure and Composition of Postsynaptic Densities
… which is composed of signaling, scaffold and cytoskeletal proteins, supports and organizes neurotransmitter receptors within the synaptic membrane in addition to bridging signaling with the actin cytoskeletal network. The protein composition and structure of PSDs is known to change in response …
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Unravelling the molecular mechanisms of HIV associated neurocognitive disorders through mass spectrometry-based proteomics
… gene expression machinery (nucleic acid binding proteins), which suggests that HIV-Tat is involved in preparing the host cell for altered transcriptional and translational activity. We also found cytoskeletal dysregulation in response to HIV-Tat treatment. The 24-hour time point of the time …
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Chlorpyrifos and chlorpyrifos oxon induce neurite retraction and cytoskeletal disruption in mouse N2a cells and human neural progenitor stem cells
… and to relate toxicity to the regulation of cytoskeletal proteins involved in neural differentiation. At 3 μM, both compounds reduced the numbers of axon-like processes in pre-differentiated N2a cells, as indicated by morphometric analysis of carboxyfluorescein succinimidyl ester-labelled …
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