Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 479 for “"cytoskeletal"”.
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Cytoskeletal organization in the osteoclast
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Cytoskeletal Networks Driving Presynaptic Plasticity
… both of these hurdles. After mapping presynaptic cytoskeletal signaling pathways in the mouse brain, I discovered a new mechanism of presynaptic plasticity that is driven by action potential-coupled actin remodeling.</p><p>Presynaptic terminals cannot be biochemically purified away from …
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Structual Visualization of Cytoskeletal Force Tranduction
<p>Cells adhere to their surroundings, mechanically interfacing their intracellular actin cytoskeletons with their local extracellular environments. This enables contractile forces generated by myosin motors to mediate transduction of mechanical cues into biochemical signaling pathways by unclear …
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Collective dynamics of astrocyte and cytoskeletal systems
Advances in imaging and biological sample preparations now allow researchersto study collective behavior in cellular networks with unprecedented detail. Imaging the electrical signaling of neuronal networks at the cellular level has generated exciting insights into the multiscale interactions …
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Effect of oncomodulin on cytoskeletal actin dynamics.
Cochlear outer hair cells (OHCs) contribute to the fine sensitivity of the mammalian auditory system by serving as a feedback mechanism in response to sound. Regulation of filamentous and globular actin may contribute to the reversible shape changes critical to OHC function. Previous studies have …
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Cytoskeletal Remodeling in Fibrous Environments to Study Pathophysiology
… and physiological 3D gels have elucidated cytoskeletal reorganization, our understanding on how cells adapt to natural fibrous microenvironments and regulate their behavior in response to specific ECM biophysical cues including fiber size, spacing, alignment and stiffness remains in …
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Localization of Cytoskeletal Elements in Teleost Retinal Pigment Epithelium
The G.3.5 antigen (Mr = 100,000) has been localized in brain, cerebellum, skeletal, cardiac, and smooth muscle tissues using the G.3.5 mAb, and has been described as an IFAP on the basis of its co-localization and co-isolation with desmin. Through biochemical analysis, the G.3.5 antigen was found …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… adipocyte mechanical response, including actin cytoskeletal remodeling. This dissertation aims to develop an in vitro model of healthy/diseased AT to explore the effect of microenvironmental cues on adipocyte function and actin cytoskeletal remodeling. The first aim is to study (1) the crosstalk …
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Cell compliance: cytoskeletal origin and importance for cellular function.
… the mechanical behavior of one cell type using cytoskeletal drugs. These migration experiments have been carried out in 2D and 3D migration assays. Furthermore, the influence of the stiffness of the surrounding material on the migration behavior has been investigated. After relating functional …
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Cell Mechanics: From Cytoskeletal Dynamics to Tissue-Scale Mechanical Phenomena
<p>This dissertation explores the mechanics of living cells, integrating the role of intracellular activity to capture the emergent mechanical behavior of cells. The topics covered in this dissertation fall into three broad categories : (a) intracellular mechanics, (b) interaction of cells with the …
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Engineered Cytoskeletal Arrays Reveal Mechanisms Of Membrane Transport And Tubulation
Within the cell, cytoskeletal molecular motors transport and remodel membrane-bound cargos along microtubule and actin filament tracks. Typically, there are multiple actin and microtubule motors attached to the same cargo, which must coordinate to navigate a complex cytoskeletal environment and …
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Fluorescence laser tracking microrheology for quantitative studies of cytoskeletal mechanotransduction
… characterizes the solid-like vs. liquid-like cytoskeletal behavior from measurements based on endocytosed micron-sized beads, independently of probe size or surface chemistry. FLTM also demonstrates the existence of two distinct rheological regimes on the cell surface and in the cell interior: …
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The effects of membrane and cytoskeletal mechanics on cell adhesiveness
The cytoskeleton, the internal network of filaments that regulates cell shape and structure, has been implicated in several critical aspects of cell adhesion. Its role, however, has primarily been demonstrated as a component of the numerous intracellular signaling events that regulate cell surface …
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Analyzing GFP-tagged cytoskeletal protein colocalization in human carcinoma cells
Cytoskeletal proteins function as dynamic, complex components involved in cellular structure and signaling. Characterizing the roles of such proteins would greatly benefit many research areas, including the study of cancer and protein-related diseases. There is currently no accurate, high …
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Cell Topology Change by the Physical Engagement of Neighboring Cytoskeletal Networks
… with neighboring zones of distinct actin cytoskeletal networks and regulators, such as lamellipodium and lamella in migratory cells, branched and unbranched actin networks at cell-cell contacts, and concentric rings of Rho family GTPases during wound healing. Neighboring networks can …
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Regulation of Mical Redox Post-Translationally-Driven F-Actin Cytoskeletal Dynamics
The actin cytoskeleton is critical for multiple diverse cellular behaviors, including the ability of an axon to form, extend, navigate, and synapse with its target. Therefore, an important goal is to understand the mechanisms that regulate it. We have been studying one of the largest families of …
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Organization and expression of genes encoding cytoskeletal proteins in Plasmodium falciparum
Contains fulltext : mmubn000001_083349839.pdf (Publisher’s version ) (Open Access)
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The Cytoskeletal Mechanisms of Cell-Cell Junction formation in Endothelial Cells
Intercellular adhesions are essential for compartmentalization and integrity of tissues in an organism, cell-cell communication, and morphogenesis. The actin cytoskeleton and associated proteins play a vital role in establishing and maintaining cell-cell adhesion. However, the procedure by which …
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Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions
… the tyrosine phosphorylation of several cytoskeletally associated proteins. These tyrosine phosphorylations correlate well with focal adhesion breakdown. Furthermore, addition of a recombinant, constitutively active tyrosine phosphatase inhibits both the tyrosine phosphorylations and the …
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