Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"cytosine deamination"”.
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
… landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and cytosine analogs to uracil and the corresponding uracil analogs. During replication, uracil and uracil analogs codes as …
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Exploring the origins of DNA using synthetic biology Alannah Marie
… the transition from U-DNA to T-DNA was driven by cytosine deamination (Poole et al., 2001), which would lead to mutagenic generation of U in the genome via C to U deamination events. However, a transition to T is an indirect fix to this problem; it enables identification of mutagenic U:G pairs …
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Genetic and biochemical studies of human apobec family of proteins
… of proteins in higher vertebrates converts cytosines in DNA or RNA into uracil. These proteins have essential roles in either innate immunity or adaptive immunity. Recently, AID has also been implicated in DNA demethylation in the context of early embryogenesis in mammals. This is partly …
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Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH
Die spontane hydrolytische Desaminierung von Cytosin zu Uracil ist eine der häufigsten DNA-Modifikationen während des zellulären Stoffwechsels. Um dieser mutagenen Wirkung zu widerstehen, entfernen die meisten Organismen Uracil-Reste aus der DNA mittels Basen-Exzisionsreparatur (BER). Diese wird …
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Biochemische, molekularbiologische und genetische Untersuchungen über strukturelle Voraussetzungen für DNA U-Endonukleaseaktivität in der ExoIII-Familie von DNA Reparaturenzymen
Eins der gravierendsten Probleme in jedem Organismus sind die spontane hydrolytische DNA-Schäden. Das Problem der DNA-U-Reparatur wurde bis heute sorgfältig in thermophilen und hyperthermophilen Archaeen untersucht. Dabei wurde ein neuartiger Reparaturweg entdeckt, der von einer DNA-U Endonuklease …