Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 53 for “"cytoplasmic tail"”.
-
The Role Of The Membrane Proximal Region Of The M2 Cytoplasmic Tail In Virus Replication
… proximal region, residues 46-69, of the M2 cytoplasmic tail during virus replication. A cholesterol recognition/interaction amino consensus: CRAC) motif, previously identified in the membrane proximal region of M2 in some influenza A virus strains, was suggested to play a role in virus …
-
A Biophysical Investigation of HIV-1 Envelope Cytoplasmic-Tail Mediated Retention in the Gag Lattice
… are dependent on the Gag matrix (MA) and Env cytoplasmic tail (CT) domains. Env laterally diffuses on the host cell plasma membrane until encountering a budding Gag lattice, where it is retained until particle scission and release. The mechanism of Env entry and retention in the lattice …
-
Functional analysis of murine CD43 shedding : a role for the CD43 cytoplasmic tail in nuclear signalling
… shedding is a requirement for release of the cytoplasmic domain and its translocation to the nucleus. In support of our hypothesis, we confirmed that the CD43 cytoplasmic domain is localized in the nucleus and is modified by SUMO (small ubiquitin-like modifier) peptides. In an attempt to …
-
The Cytoplasmic Tail of Mhc Class I Molecules Plays A Critical Role In Dendritic Cell-Induced T Cell Immunity
… several findings have suggested that the cytoplasmic tail of MHC class I plays a functional role in the regulation of CTL immune responses. For example, our previous studies demonstrated that exon 7-deleted MHC-I molecules not only showed extended DC cell surface half-lives but also …
-
Structure and dynamics of full-length M2 protein of influenza A virus from solid-state NMR
… to an amphipathic helix (AH) and a Cterminal cytoplasmic tail (63-97). The TM domain of M2 is responsible for proton conduction ant the ectodomain has been the target for vaccine development. The cytoplasmic tail has been implicated in M2 interaction with other viral proteins from mutagenesis …
-
Molekularbiologische und funktionelle Charakterisierung neuer "Chicken Ig-like" Rezeptoren
… were encoded by separate exons and the long cytoplasmic tail (in case of inhibitory receptors) was encoded by two exons, the last exon containing the ITIMs. The exon/intron boundaries conformed to the gt-ag rule and the exon phases were highly conserved. In conclusion, the genomic …
-
Characterization of the Human Adenovirus 19a E3/49K Protein
… with a large N-terminal domain and a short cytoplasmic tail of 19 amino acids (aa). The N-terminal part contains three repeat regions (R1-3) of about 80 aa each with R3 exhibiting a significant homology to immunoglobulin-like domains. This study shows that 49K is a highly glycosylated …
-
Analysis of factors that affect pseudotyping in retroviruses
… the HIV-1 accessory protein Vpu, the Env cytoplasmic tail, and cell line-specific host factors. Vpu has been identified to negatively affect Env protein from gibbon ape leukemia virus (GaLV) in a similar way that it down-modulates native targets, CD4 and BST-2/tetherin. We take advantage …
-
The degradation of membrane proteins from the mammalian endoplasmic reticulum
… requirements of US2 and US 11, the 30 residue cytoplasmic tail of MHC class I molecules was mutated. US2 can degrade MHC class I molecules with a cytoplasmic tail shortened to 10 residues or lengthened, by the fusion of GFP to the C-terminus, to several hundred residues.
-
The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma
… compartments has been characterized as a cytoplasmic tail dependent process. The MHC-I cytoplasmic tail possesses two conserved phosphorylation sites, a tyrosine (Y320) and serine (S335). It is known that MAPK pathway activation can induce a phosphorylation signaling cascade in tumor …
-
The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… its receptor DCC. I have shown Trim9 binds the cytoplasmic tail of DCC and also binds Ena/VASP proteins and Myosin-X, which are cytoskeletal effectors downstream of Netrin-1. I discovered that inhibition of Trim9 ubiquitin ligase activity specifically blocks Netrin-1 induced cortical branching. …
-
Studies on the structural organization of Golgi complex
… the importance of the above Golgi protein's cytoplasmic tail domain in Golgi targeting and retention. we found that the cytoplasmic tail could be lengthened considerably (3-4 fold) and SialyIT and GalT still accumulated in a perinuclear, Golgi-like distribution with little ER background. One …
-
The molecular and cellular defect underlying autosomal recessive hypercholesterolemia (ARH) in the first kindred identified in South Africa
… is presumed to facilitate interaction of the cytoplasmic tail of the LDLr with the internal protein matrix required for the receptor internalisation.
-
Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
… determines binding of the Pafah1b complex to the cytoplasmic tail of the receptor. Mice expressing this L838R mutation were created using ES cell homologous recombination techniques and will be useful in exploring the effects of the mutation in brain development and synaptic function in vivo. …
-
An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
… gene were identified, differing only in their cytoplasmic tails, with one highly expressed in the liver and the other highly expressed in the brain. The liver isoform of ADAM11 was induced by dietary cholesterol and the LXR transcription factor. In order to study the function of this gene, this …
-
Characterization of a Novel Signaling Motif in the CD3 ε Subunit of the T Cell Receptor
… identified an additional signaling motif in the cytoplasmic tail of CD3 ε that we termed the basic-rich stretch (BRS). Biochemical analyses revealed that this motif uniquely interacted with the serine/threonine kinase, G protein-coupled receptor kinase 2 (GRK2). Interactions between the BRS and …
-
Single Molecule Imaging of Human Immunodeficiency Virus Type-1 (HIV-1) Envelope Glycoprotein Dynamics Identifies Viral Elements Contributing to Infectious Particle Assembly
… proteins are likely to interface – in the Env cytoplasmic tail, and the Gag matrix domain. Identification of these and other critical viral elements during assembly of infectious virion could open the door to methods and therapeutics in abolishing the spread of this deadly viral infection.</p>
-
Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins
… platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and Syk kinases, but shows a partial rather than an absolute dependence on adapter SLP-76 for activation of PLC\(_y\)2. The aim of this thesis is to understand some of the key differences in these …
-
Biological effects of trogocytosis on CD4+ T lymphocytes
… C 88-103) and with or without a GFP-tagged cytoplasmic tail as antigen presenting cells for T cells from a peptide-specific TCR transgenic mouse. Using a combination of high-resolution microscopy and flow cytometry, In this thesis I showed that the trogocytosed material is retained on the …
-
Biological effects of trogocytosis on CD4+ T lymphocytes
… C 88-103) and with or without a GFP-tagged cytoplasmic tail as antigen presenting cells for T cells from a peptide-specific TCR transgenic mouse. Using a combination of high-resolution microscopy and flow cytometry, In this thesis I showed that the trogocytosed material is retained on the …
Page 1 of 3