Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"cytopathic effect"”.
-
Mycoplasma Pneumoniae Infections - Role of Nucleotide Metabolism in the Mechanism of Pathogenesis
… method by which Mycoplasma pneumoniae induces a cytopathic effect (CPE) in host cells is not clearly defined. This study was designed to delineate some of the factors involved in the mechanism of pathogenesis of M. pneumoniae infection. Two major areas affecting the host-parasite interaction were …
-
Development and Evaluation of an Isospora Suis Sporozoite Neutralizing Antibody Assay in Swine Testicular Cells
… sporozoites by immunofluorescence and the cytopathic effect in ST cells. A monoclonal antibody against the apical complex of I. suis sporozoites inhibited the infection of sporozoites in vitro. Hyperimmune sera produced in goats and guinea pigs inhibited sporozoite infection in ST cells. …
-
Suppressive effect of a nucleic acid-hydrolyzing recombinant antibody (3D8) on viral multiplication
… against VSV multiplication and VSV-induced cytopathic effect (apoptosis) was observed. When HeLa cells that stably express 3D8 scFv protein were infected with VSV (MOI=0.1), 3D8 scFv-expressing cells showed 40% reduction in the viral G protein expression level with flow cytometry and 1 x 10³ …
-
Effect of Chinese Knotweed Extract on HSV-1 Infection of Vero Cells
… and latent states has made the development of effective treatments challenging. Polygonum multiflorum (Chinese Knotweed, CK) is a perennial plant local to the south central regions of China. The thunb (root) constituents of this compound have been used in traditional Chinese medicines to treat …
-
Identification and characterization of cell-adapted mutations in West Nile Virus and replicons
… cell’s stress and apoptotic responses and a noncytopathic infection. As a result, little cytopathic effect and apoptotic death were observed in cells infected with NS2A or 3’ UTR deletion WNR mutants compared to cells infected with wt WNR genomes. This lack of death may have been attributed to …
-
Characterization of a Newly Identified Alphavirus, Eilat Virus
… a variety of insect cells with little overt cytopathic effect. However, in contrast to all other mosquito-borne alphaviruses, EILV was not able to infect mammalian or avian cell lines. EILV host range restriction was present at attachment and entry, as well as at the RNA replication level, …
-
Development of a New Class of Viral Disinfectants: Enzymatic Inactivation of Sa-11 Rotavirus
… and toxic disinfectants. In this study, the effects of bacterial proteases as a new type of disinfectants on simian rotavirus (SA-11) were analyzed. SA-11 rotavirus replicates in cells causing cytopathic effect (CPE) and is similar in protein composition to cattle and swine RV. Preliminary …
-
Vaccinia virus BTB-Kelch proteins
… C2L also causes different plaque morphology and cytopathic effect in cultured cells. The mechanisms underpinning these observations were unknown, and hence were the objectives of this study. Besides, the interaction between Cul3 and VACV BBKs, the cellular substrates of A55, C2 and/or F3, and the …
-
Charakterisierung von reptilienpathogenen Paramyxoviren und Analyse des prokaryotisch exprimierten partiellen Fusionsgens
… as paramyxoviruses showing characteristic cytopathic effect, was carried out by electronmicroscopy and RNA-PCR of two partial genes (L and F). After sequencing RNA-PCR amplicons, identical sequences were found for the reptilian paramyxoviruses (RPMV) isolated in the same outbreak from …
-
Cellular factors and viral elements for parvovirus replication
… determined by three techniques: observation of cytopathic effect, detection of virally-coded proteins by indirect immunofluorescence, and transient DNA replication assays. We report that the mutant clone containing duplicate sequences of the (mismatched) nucleotides numbered 46 to 57 (BLOP) was …
-
Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… study, N. fowleri trophozoites showed the highly cytopathic activity and cytotoxicity against rat microglial cells by the morphological observation and 51Cr release assay. In the present study, to determine whether a pathogenic N. fowleri lysate shows the cytopathic effects against primary …
-
An exploration of the interplay between HSV-1 and the non-homologous end joining proteins PAXX and DNA-PKcs
… innate sensor of cytoplasmic viral DNA, but the effect of DNA-PKcs on HSV-1 infection has not been fully explored. Murine skin fibroblasts (MSFs) derived from wild type and PRKDC-/- (DNA-PKcs deficient) mice were cultured ex vivo and used for innate immune studies. Although HSV-1 was able to …
-
Intraspecies typing of orthopoxviruses
… the ceiling temperature, rabbit virulence, cytopathic effect in cell monolayers and sensitivity to anti-vaccinial serum which is characteristic of vaccinia, and is regarded as an isolate of vaccinia. The other five had a lower ceiling temperature, were avirulent when inoculated in rabbits …