Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"cytokinesis failure"”.
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The Role of Polyploidy in the Liver and Its Implications for Cancer Therapy
… polyploidization mainly occurs through cytokinesis failure, we hypothesized that inhibiting cytokinesis could be an effective strategy to suppress liver tumorigenesis while preserving normal liver function. Therefore, we inhibited cytokinesis via Anln knockdown in multiple models and …
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The evolution of centrosome and chromosome number in newly formed tetraploid human cells
… in newly formed tetraploid cells generated via cytokinesis failure. I uncover the mechanism driving the process and build a mathematical model that captures the experimentally observed dynamics. Next, I investigate karyotypic heterogeneity in newly formed tetraploid cells and their counterparts …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… cycle progression. Centrosome amplification and cytokinesis failure are hallmarks of genomic instability, often observed in precancerous lesions and advanced malignancies. The p53 tumor suppressor pathway, acting through the Caspase-2–MDM2–p53 signaling axis, provides a crucial surveillance …
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Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… cytoplasm to generate two separate daughters. Failure of any part of this process can have drastic effects and ultimately defects in cell division have been implicated in many diseases, such as cancer. Phosphorylation is extensively used during cell division to regulate the activity, function, …
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The effects of chromosome number changes on mitotic fidelity and karyotype stability
The correct number of chromosomes is important for the maintenance of healthy cells and organisms. Maintenance of a correct chromosome number depends on the accurate distribution of chromosomes to the daughter cells during cell division, and errors in chromosome segregation result in abnormal …
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Quantitative Aspects of Interface Remodeling During Germband Extension
… In <em>onr</em> and <em>fun</em> mutant cells, cytokinesis is disrupted early in furrow ingression, leading to cytokinesis failure. Computational analysis was used to quantitatively compare wild-type versus <em>onr</em> and <em>fun</em> mutant cells. The results demonstrate that anaphase cell …
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HeLa에서 K-ras 과발현시 활성산소 발생에 의한 핵모양의 이상의 발생과 이중핵/다핵 세포 증가 현상 연구
Polyploidy and abnormal nuclear shapes are well known characteristics of cancer cells. K-Ras is frequently mutated in many cancers. One of the oncogene mutants, K-RasV12 has been reported to generate reactive oxygen species (ROS). We recently observed that increased ROS generates polyploidy and …