Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1585 for “"cytokines"”.
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Equine interferon-gamma and associated cytokines
Cytokines are small proteins or glycoproteins that mediate cellular growth and differentiation and regulate immune responses. Upon encounter with antigen, CD4+ T cells are able to influence the character of the immune response elicited through the expression of distinct types of cytokines. Thl …
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Myogenic functions of muscle-derived cytokines
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Cancer immunotherapy with Mucin-1 and cytokines
… contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, and ovary making an ideal target for immunotherapy. MUCl coupled to oxidised mannan (MFP), forms …
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Muscle cell-derived cytokines in muscle regeneration
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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The role of fibrolast-derived cytokines on melasma
… we studied the role of fibroblast-derived cytokines on the development of melasma. We collected the specimens of perilesional normal site and lesional site by 2 mm punch biopsy technique on the faces of 50 melasma patients. We performed on the specimens to stain of hematoxylin-eosin, …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
… skeletal muscle cells are prolific secretors of cytokines and other soluble factors. In fact, myoblasts express and secrete different cytokines at distinct points during proliferation and the stages of differentiation. These observations gave rise to the idea that perhaps muscle cells could …
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Inflammatory Response Following Hemorrhagic Stroke: The Role of Cytokines
… to any injury, the immune system releases cytokines to recruit immune cell activation and promote inflammation. But after hemorrhagic stroke, whether aneurysmal subarachnoid hemorrhage (aSAH) or intracerebral hemorrhage (ICH), the rapid increase in inflammation and an imbalance of …
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
… potent cancer immunotherapies, immunostimulatory cytokines have been shown to elicit anti-tumor immune responses in preclinical studies, but their clinical application is limited by severe immune-related adverse events upon systemic administration. None of the current delivery strategies can fully …
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Cytokines and human endometrial function: Abnormalities in recurrent miscarriage women.
… local autocrine and paracrine factors, such as cytokines. The role of cytokines in the human endometrium still remains to be determined, but they are thought to play an important role in the implantation process. This study has therefore focused on the expression of pro-inflammatory cytokines in …
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Cytokines and chemokines in the pathogenesis of low back pain
… structural failure, as seen in IVD degeneration. Cytokines are implicated in this process, several studies have identified that Interleukin-1 (IL-1) and Tumour Necrosis Factor-α (TNF-α) expression is increased in degenerate IVDs compared to their normal counterparts. Furthermore, it has been shown …
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Macrophage cytokines as correlate of differential resistance to African trypanosomiasis
… The expression of mRNA and/or production of cytokines (IL-6, IL-10, TNF-α, TGF-β1 and IL-12) and nitric oxide (NO) by macrophages from C57Bl/6 and BALB/c mice in response to 'T. congolense' or 'T. brucei' were studied. The bone marrow-derived macrophage cell line (BALB.BM) and bone …
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Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA
… inhibits CXCL1 and LPS-induced pro-inflammatory cytokines, chemokines, kinases, transcriptional factors, and apoptotic gene.
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Gonadotrophins and cytokines in ovarian epithelial cancer / John Alexander Latimer
This thesis compares the rates of mitotic activity of the ovarian surface epithelium (OSE) and the peritoneal mesothelium (PM) and the effects of ovarian hyperstimulation using a rodent model. The study provides also information about cytokine expression and production in benign and malignant …
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Modifying the lung microenvironment through gene delivery of immunomodulatory cytokines
… inflammation, including overproduction of cytokines, reactive oxygen species, and significant infiltration of immune cells to the injury site. In some patients, this heightened immune response can cause substantial lung damage. Understanding how to control these immune responses and restore …
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Elucidating the Role of RanBP2/Nup358 in the Regulation of Cytokines mRNAs
… factor α (TNFα) mRNAs, which encode for two cytokines prominently upregulated in ANE1. We showed that RanBP2 SUMOylates Argonaute (AGO) proteins, enhancing their interaction with target mRNAs and their binding partner GW182 to promote miRNA-mediated silencing of cytokine mRNAs. This …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
… from MS and non-MS individuals. Pro-inflammatory cytokines (interleukin-1beta , tumour necrosis factor and interferon-gamma) increased the expression of both CCL2 and CXCL10 by astrocytes at the mRNA and protein level, as determined by real time PCR and enzyme linked immunosorbent assays (ELISA), …
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The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… cascade. However, the production of inflammatory cytokines and recruitment of immune cells in the early stages of fracture repair, and the implications for these processes on effective fracture repair remain incompletely understood.For the first aim of the dissertation, we examined gene expression …
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Regulation of Platelet-Activating Factor Acetylhydrolase by Oxidized Phospholipids and Proinflammatory Cytokines
… manner. Although both MO and DC responded to the cytokines, preliminary experiments suggested that induction of PAFAH is more robust in DC than MO. Cytokine-treated cells exhibited increased PAFAH activity in their culture supernatants that correlated with increased PAFAH protein levels. Treatment …
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