Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"cytokine storm"”.
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… the hyperactive immune system causes acute cytokine storm, cytopenia, and local tissue damage. Current preclinical models of severe influenza, in small animal models and in vitro, fail to recapitulate the human immune response to severe viral infection accurately. Here, we bioengineered a …
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Characterization of pro- and anti-inflammatory immune responses in SARS-CoV-2 infection
… stimulates the immune response to produce many cytokines and chemokines, the proteins imperative to fight a brewing infection. This response begins through recognition of pathogen-associated molecular patterns (PAMPs) from the virus, or from other signatures characteristic of tissue damage, …
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INFECTION OF MACROPHAGES BY SARS-COV-2: IMPLICATIONS FOR VIRAL SPREADING AND IMMUNE RESPONSE
… their ability to regulate production of cytokines and growth factors in inflammatory conditions, they are likely involved in the cytokine storm that characterizes COVID-19 severe cases. Though a clear understanding on how macrophages directly sense and how they react to SARS-CoV-2 is …
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De novo design of protein binders as functional therapeutics
… minibinder antagonists as immune modulator for cytokine storm; in Chapter 3, I report the design of endocytosis ligands for target degradation and signaling amplification. Overall, the minibinder is a brand-new drug modality/platform with advantages of ultra-stability, high-specificity, robust …
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Characterization of Influenza:Streptococcus pneumoniae synergistic disease and potential for disease alleviation via sphingolipid therapy
… host inflammatory response, known as the "cytokine storm." However, the nature of dual infection has not been well-studied in the elderly demographic. Therefore, we aim to better define this disease synergy in an aged mouse model and explore potential therapeutic alternatives that could be …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… the immune response generated during ALF using cytokine antibody microarrays, we observed 1) that the macrophages and neutrophils appeared to be responsible for the cytokine storm generated during ALF, and 2) MSO pretreatment reduced the entire measured cytokine response. </p> <p>Using ELISA …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… lung injury that is associated with dysregulated cytokine production and decreased lung compliance. No specific treatment exists for ARDS due to the limited understanding of its pathogenesis. We have developed an influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) …
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Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
… therapy also induces an intratumoral "cytokine storm," potentially re-polarizing the tumor microenvironment into one that is immunologically anti-tumor. We also identify cross-talk between NK cells and macrophages to induce intratumoral recruitment of neutrophils but with the requisite …
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Cardiology Implications of ED COVID-19 Patients in an Underserved Rural Health Care Environment
… Framework: </strong>Inflammatory cytokine response syndrome (i.e., cytokine storm) guided this study.</p> <p><strong>Approach/Method:</strong>. Retrospective descriptive correlational design. Data were extracted from the electronic health records (EHR) of patients presenting to the …
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A non mouse-adapted dengue virus strain as a new model of severe dengue infection in AG129 mice
… of D2Y98P (via the ip. and sc. route) induced a cytokine storm, massive organ damage, and severe vascular leakage, leading to hemorrhage and rapid death of the animals at the peak of viremia. In contrast, very interestingly and uniquely, ip. infection with a low dose of D2Y98P (10^4 PFU) led to …
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Análise do perfil epidemiológico e molecular do SARS-CoV-2 em dois municípios do estado da Bahia entre 2020 e 2022.
… inflammatory pathways in severe cases, including cytokine storm induction and downregulation of anti-inflammatory responses. Genomic analysis indicated the circulation of multiple lineages, including Alpha and Gamma, suggesting successive viral introduction events. In Salvador (n=174), most …
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Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity
… to toxicity associated with tumor-cell lysis and cytokine storm. Clinical trials will now be addressing the targeting of minimal burdens of CD19<sup>+</sup> malignancy as patients are enrolled earlier in their disease course and receive concomitant chemotherapy. It is likely that the existing …
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Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model
… and the resulting effector molecules such as cytokines, chemokines and type I IFNs. MPI macrophages are susceptible to IAV infection but this results abortive replication, following established understandings. However, MPI macrophages are much more sensitive to influenza infection than non-AM …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
… The virus load leads to the massive release of cytokines, an unregulated cytokine storm which develops into sepsis-like haemorrhagic fever characterised by tissue damage, loss of vascular integrity and multi-organ failure. The spike glycoprotein (GP1,2), the only surface protein within the Ebola …