Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"cytokine signaling"”.
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Structural analysis of cytokine signaling modulators
<p>The N-linked glycans attached to cytokine receptors modulate signal transduction by interacting with galectin-3 and generating a cell surface lattice. This opposes constitutive endocytosis and reduces the thresholds for cytokine signaling. The preferred ligands for galectin-3 are the …
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Microfluidic devices for studying early response of cytokine signaling
… and reproducible data for studies of cell signaling events, especially at early stages. These cell signaling events are difficult to be investigated by conventional techniques. The thesis reports the development not only of a cell population analysis method, but also of a single-cell …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals among T-cell clones have been generally attributed to differences in TCR specificity. This thesis describes the novel …
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Influences of Host Cytokine Signaling on KSHV Infection in Tonsil-derived B Lymphocytes
… Castleman disease (MCD) and KSHV inflammatory cytokine syndrome (KICS). Existing research reveals that KSHV has developed numerous strategies to alter host cytokine signaling activities to facilitate viral persistence and escape host immune surveillance.</p> <p>Despite three decades of …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… identified WP1130 as a potent inhibitor of Jak2 signaling. However, unlike AG490, WP1130 did not directly inhibit Jak2 kinase activity. Our results show that WP1130 induces rapid ubiquitination and subsequent re-localization of Jak2 into signaling incompetent aggresomes. In addition to Jak2, …
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Insights into Virus-Host Interactions: Regulation of Cytokine Signaling Is a Virulence Determinant of West Nile Virus
… in its ability to disrupt IFN-induced JAK-STAT signaling. However, replication of MAD78 was rescued in cells lacking a functional IFNalpha /beta receptor (IFNAR). Consistent with this, MAD78 virulence was unmasked upon infection of mice lacking IFNAR. The regulation of IFN signaling was …
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Molecular and biochemical characterization of suppressor of cytokine signaling-3 (SOCS-3) and SH2-containing phosphatase 1 (SHP-1) in the context of G-CSF) and erythropoietin signaling
In this work interactions of SOCS-3 with the EpoR were studied since there was some evidence from the literature that SOCS-3 would bind to more than one recruitment site on the Epo receptor. For that purpose SOCS-3 was cloned, expressed and purified for subsequent biochemical studies. These …
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… of proteins involved in the down-regulation of cytokine signaling have been described recently: (i) SH2 domain containing protein tyrosine phosphatases (SHP), (ii) suppressors of cytokine signaling (SOCS) and (iii) protein inhibitors of activated STATs (PIAS). We have analyzed the interplay of …
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
… secretion of antiviral factors called cytokines. Previous work has identified antiviral cytokines in the placenta that restrict congenital viral infections without inducing excessive inflammation or immune pathology, such as Type III interferons (IFNλ). However, our understanding of how …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
… to serve as secondary messengers in integrin and cytokine signaling pathways which stimulate chondrocyte production of ECM-degrading enzymes called matrix metalloproteinases (MMPs). Fibronectin fragment (FN-f) stimulation of the &alpha5&beta1 integrin increases intracellular levels of ROS in …
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Cellular Mechanisms Involved in Reactive Carbonyl and Hyperinsulinemia Enhancement of Diabetic Complications
… disrupts cell survival and impairs IRS-dependent cytokine signaling which may alter the immune response and contribute to the accelerated proinflammatory conditions of diabetes mellitus. Furthermore, these findings suggest that elevated blood MGO levels may increase the cytotoxic effects of …
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… that PAS kinase may counter-regulate insulin and cytokine signaling.
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… aligned with immune regulation, tumorintrinsic signaling, metabolism, and neuroimmune interactions. SHAP-based interpretation and pathway analysis highlight key resistance-associated programs, including immunosuppressive cytokine signaling, metabolic signaling, and neuroactive pathways such as …
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Combinatorial strategy to generate antibody-cytokine fusions with "activity-on-demand" for cancer therapy
… therapeutic outcomes in a fraction of patients. Cytokines are a class of immunomodulatory proteins with the potential to harness the activity of the immune system and recombinant preparations of certain cytokine payloads have gained marketing authorization for cancer therapy. However, due to …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
<p>Multiple signaling pathways control protein synthesis by modulating translation initiation factors. Map Kinase Integrating Kinase 1 (Mnk1) relays signals to its major downstream target eIF4E. Activation of Mnk1 and subsequent phosphorylation of eIF4E results in changes in translation rates for …
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Diet Modifies the Neuroimmune System by Influencing Macrophage Activation
… from classical to alternative activation. Cytokines in the local microenvironment influence the activation state of macrophages. During activation of the neuroimmune system, antigen presenting cells, such as macrophages, produce cytokines that mediate communication of the peripheral immune …
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The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation
… shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle metabolism. Intriguingly, skeletal muscle has been demonstrated to gain favorable inflammatory cytokine-mediated metabolic adaptations in the context of exercise training. This paradigm suggests a role for …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… artery smooth muscle cells (hCASMCs) and cytokines involved in inflammation. Insulin-like growth factor (IGF-i) is one of the most potent inducers of proliferation in hCASMCs, mainly through the activation of phosphatidyl inositol3 (Pl3)-Kinase and mitogen induces protein (MAP) Kinase …
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Die Rolle der Janus-Kinasen-spezifischen Insertion (JSI) in JAK2
The Janus Kinase JAK2 is activated by IL-6-type-cytokines. Furthermore it plays an important role within the signal transduction of other cytokines, as for example erythropoetin and growth factors. In the Institute for Biochemistry of the RWTH Aachen, a structured model of the Kinase domain of JAK …
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Effects of DFO-Induced Hypoxia on Key Signaling Mediators
… analysis. Due to activation, the suppressors of cytokine signaling (SOCS) proteins, negative regulators of the JAK/STAT pathway, were investigated and detected via RT-PCR. These results suggest that there is an up-regulation of the SOCS proteins under hypoxia, and it may play a role in a form of …
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