Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"cytokine response"”.
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
Dendritic cell (DC) interaction with infectious prions (PrPSc) represents an important part of prion pathogenesis. Previous studies have shown that DCs are likely among the first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC …
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The Impact of Mental Challenge on Indicators of Endothelial Function in Obese Individuals
… however, the underlying mechanisms for these responses have not been clearly elucidated. The purpose of this study was to compare the effects of mental challenge on forearm blood flow, total antioxidant capacity (a measure of oxidative stress), the release of norepinephrine (NE; stress induced …
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Evaluation of immunomodulatory compounds for identification of an anti-herpetic innate immune response profile
… by vaginally expressed TLR and elicit specific cytokine response profiles. As an initial step in identifying cytokines that are associated with resistance to HSV-2 infection, selected TLR agonists were evaluated in human cell culture or small animal models. An assay scheme was developed to …
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Cytokine Dysregulation Promotes HPV Persistence
… are resolved by the cell-mediated immune response of the host. However, in a small subset of individuals exposed to genital HPV, infection persists and can progress to cervical carcinoma. The inability to maintain the appropriate cytokine milieu in the cervical mucosa has been implicated …
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Cellular immunity of naïve and BCG vaccinated neonates
… is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. …
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Toll like Receptor 4-Mediated Immune Responses in the Bladder Epithelium
… to contend with the vigorous local innate immune response that is initiated by engagement of surveillance molecule TLRs. TLR4 appears to be not only exclusively expressed on superficial BECs but also critical to triggering robust local innate immune responses. TLR4 recognizes Gram-negative …
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Host response to Rift Valley fever virus infection
… information has been published on the host response to infection by RVFV. To date, there is little detailed data directly comparing the host response to infection with RVFV and correlation with viral pathogenesis. My goal was to be able to discern the host response to infection and to …
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Local immunopotentiation of the bladder in response to BCG immunotherapy
… a standardized protocol for measuring urinary cytokines, we noted that BCG induces a mixed cytokine response, with a predominance of TH1 cytokines. Immune cells, bladder cancer cells and normal urothelium all produce cytokines and adhesion molecules, constitutively and on stimulation with BCG, …
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Semiquantitative und quantitative Charakterisierung der Zytokinantwort humaner Keratinozyten nach Stimulation mit Propionibacterium acnes und Koproporphyrin III
… In the present study we examined the local host response mechanism of keratinocytes 3 and 6 h after stimulation with viable and heat- killed P. acnes. Methods The quantitative expression of cytokines was measured at the mRNA level by real time RT-PCR. Results The co-incubation of keratinocytes …
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Comparison of HIV-1 specific T cell immunity in the female genital tract and blood of HIV-infected women : impact of in vitro T cell expansion on HIV-specific T cell specificity, maturational status and functional complexity
… expansion method used, generally maintain their cytokine response profile to HIV anti- gens. This study shows that HIV Gag-specific blood and cervical T cells were largely mono-functional with polyfunctional T cells being detected in women with high blood CD4 count and low plasma viral load. This …
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Ribonuclease H2, RNA:DNA hybrids and innate immunity
… Nucleic acids can potently stimulate this response and trigger a series of signalling cascades leading to cytokine production and the establishment of an inflammatory state. Mutations in genes encoding nucleases have been identified in patients with autoimmune diseases, including …
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Diet Modifies the Neuroimmune System by Influencing Macrophage Activation
… from classical to alternative activation. Cytokines in the local microenvironment influence the activation state of macrophages. During activation of the neuroimmune system, antigen presenting cells, such as macrophages, produce cytokines that mediate communication of the peripheral immune …
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Evaluation of Pgg-Glucan, a Novel Immunomodulator, in in Vitro and Ex Vivo Models of Equine Endotoxemia
… - To determine the effect of PGG-Glucan on the cytokine response to endotoxin in the horse. Animals - Part 1; 6 adult horses. Part 2; 12 adult horses. Procedure - Part 1; Whole blood was collected, aliquoted, and incubated in vitro in four groups; saline control, endotoxin (LPS) (100 ng/ml), …
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… severity is driven by an aberrant immune response. In severe influenza, the hyperactive immune system causes acute cytokine storm, cytopenia, and local tissue damage. Current preclinical models of severe influenza, in small animal models and in vitro, fail to recapitulate the human immune …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… propagation and maintenance of an immune response. </p> <p>To induce acute liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When these animals were pretreated with MSO, 80% of the animals …
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Characterisation of the immunomodulatory properties of human natural killer T cells
… iNKT cell line to produce a Th1 biased cytokine response and lyse tumour cells. α-SGalCer stimulated iNKT cells also induced maturation of monocyte derived DC, and stimulated DC to produce Th1 biased cytokines. Furthermore DC matured by α-S-GalCer stimulated iNKT cells proliferated …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
… agonist of CD1d capable of triggering an immune response that results in the proliferation of a range of regulatory cytokines, including IFN-\(_y\) (Th1), as well as IL-4 (Th2). This mixed cytokine response (i.e. Th1 and Th2), combined with the “unresponsive state” of iNKT cells after activation …
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Moderate Acute Malnutrition: Inflammatory Response, Microbiota, and Potential Treatments
… of SAM and resultant attenuated inflammatory response have been characterized, there is minimal and often conflicting data available about the effects of MAM on inflammation and response to inflammatory stimuli. In this work, we observed increased inflammatory cytokine production at baseline …
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Maternal Modulation of Neonatal Immunity
… immune system is functionally immature, immune response capabilities are not the same in all newborns. The objective of this thesis was to determine development of immunocompetence and test the hypothesis that activation of maternal inflammatory immunity during pregnancy influences maturation of …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… human primary nasal epithelial cells and their response to TLR ligands. The respiratory tract itself seems to pose a contradiction given by the clinical observation that its upper portion (nasal compartment) allows the growth of bacteria, acting like a reservoir, whereas the lower portion (lung …
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