Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"cytokine profiling"”.
-
The Role of Platelets In Ovarian Carcinoma
… epithelial ovarian cancer using immunobead-based cytokine profiling coupled with the Luminex® xMAP platform. Plasma cytokines significantly associated with thrombocytosis in ovarian cancer patients were subsequently evaluated in mouse models of ovarian cancer using ELISA immunoassays. The results …
-
Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… RNA sequencing, bronchoalveolar lavage (BAL) cytokine profiling, and immune cell phenotyping revealed that female Arnt-a transgenic mice exhibited attenuated neutrophilic inflammation, reduced proinflammatory cytokine expression, and accumulation of FOXP3+ regulatory T cells. In contrast, …
-
Microbial and Immune Signatures of Stress and Antidepressants Across Sex and Generations
… in tandem with behavioral assays and multiplex cytokine profiling in rat and mouse models of chronic stress or perinatal SSRI exposure. Across studies, we demonstrate that the gut microbiome exhibits innate sex differences that are present early in life and continue to diversify with age. Aging …
-
Important role of the type VI secretion system in the virulence of an emergent human pathogen Aeromonas hydrophila: Delineating the mechanism of action of its effectors
… were substantiated by the in vivo analysis of cytokine profiling and activation of host immune cells after infection with the ÄvasH mutant supplemented with rHcp indicating that this T6SS effector inhibited production of pro-inflammatory cytokines and induced production of immunosuppressive …
-
Endogenous Stress Signaling within Human Multicellular Aggregates (Spheroids)
… or JNK phosphorylation leads to cell death. Cytokine profiling within the aggregates during the arrest and recovery process is suggestive that a cyclical cascade was in operation, leading to endogenous cytokine production of TNF-Alpha, IL-1Beta, and IL-8, thereby propagating the cellular …
-
Characterisation of surfactant protein a as a novel prophylactic means against oncogenic HPV infections
… in the presence of HPV16-PsVs, as identified by cytokine profiling. These results unveiled SP-A's versatility and substantial influence on various HPV interactions with immune cells and keratinocytes and laid the foundation for future research into the development of alternative prophylactic …
-
Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… roles in immune cell lineages.</p> <p>Luminex cytokine profiling also revealed to us that loss-of-Brd7 led to upregulation of pro-metastatic cytokine secretion like CXCL10, CCL5, CCL2, CCL20. To further delineate the effect of loss-of-Brd7 on the immune microenvironmental niche, flow cytometric …
-
Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… perform from collected stimulated saliva, and cytokine profiling from serum and gingival crevicular fluid (GCF) via Olink proteomics. Although high-risk PERK haplotypes did not show a significant correlation with clinical periodontitis or depression, carriers showed a higher prevalence of …
-
Brain Endothelial Cells Orchestrate an Anti-Encephalitic State in the Central Nervous System in Response to Peripheral Viral Infection
… identified interferons (IFNs), small antiviral cytokines, as critical to control WNV infection. However, most work examines the role of IFN in the periphery or in the CNS only post-neuroinvasion. We still do not fully understand how the CNS responds to viral infection prior to neuroinvasion. …
-
C/EBPβ Regulates Tumour Size and Microenvironment Composition in Lewis Lung Carcinoma
… overexpression increased it. Transcriptomic profiling of these models revealed two major C/EBPβ-associated programs. One comprised immune-related pathways, with gene sets linked to leukocyte migration/chemotaxis and immune signaling downregulated in the C/EBPβ knockout and upregulated with …
-
Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
… trans-genes and enriched pathways related to cytokine signalling and the citric acid cycle. Colocalisation analysis using updated CD genome-wide association summary statistics from our lab showed that the disease-associated variant likely decreased the expression of ADCY3 in immune cell …
-
Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… collagen deposition, reducing immunosuppressive cytokine signaling, and promoting anabscopal response in distant, untreated tumors. In accordance with these results, RFA may help the immune system to overcome PDAC's innate immunotherapy resistance.</p> <p>To further analyze the clinical …