Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"cytokine profiles"”.
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
… and LNG implant on cervicovaginal inflammatory profiles previously associated with HIV acquisition, among a sub-cohort of ECHO participants. This study included 167 ECHO participants at the Setshaba Research Centre in Pretoria and MatCH Research Unit in Durban, South Africa. Eleven cytokines and …
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A description of the pharmacokinetics of first line anti-tuberculosis drugs and adjunctive corticosteroid therapy in the pericardial compartment and their effect on cytokine profiles in the pericardial compartment of patients with tuberculous pericarditis
… its effect on endogenous corticosteroids and cytokines. Furthermore, the study compared the immunological response to tuberculous pericarditis in plasma and pericardium. Results: While pericardial drug exposures to isoniazid and pyrazinamide were comparable to those of plasma, there was a …
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Impact of potato protein supplementation with dietary fermentable materials on immune measures in Sprague-Dawley rats
… measures between sexes. Diet and sex influenced cytokine concentrations, populations of immune cells, and production of antibodies. Gnaw sticks had opposing effects on sexes in both fermentation and cytokine profiles, and thus they can interfere with data interpretation. Dietary supplementation …
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Response of salivary IL-8 to prolonged and interrupted sitting
… sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: …
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Studies on immunity in the male genital tract
… mucosal T cell activation and inflammatory cytokine profiles in semen in HIV?infected and uninfected men, and compare the immune milieu of the genital tract with the systemic compartment.
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Determinants of clinical phenotype in myeloproliferative neoplasms
… models were validated in an external cohort. Cytokine profiles of over 400 patients were also analysed to determine the contribution of the inflammatory microenvironment to phenotype and progression risk. Results: A total of 2035 patients were included in the analysis. 33 genes had driver …
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Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum
… of this study was to compare growth factor and cytokine profiles in canine autologous conditioned serum (ACS) to canine plasma. Blood collected from 16 medium to large breed dogs was used to produce ACS (Orthokine® vet irap 10 syringes) and citrated plasma (control). Canine-specific ELISA assays …
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Temporal profile of blood cytokine levels and placental pathology in extremely preterm infants
… between placental pathology and the temporal profiles of “cytokine” (cytokines, chemokines and growth factors) levels in extremely preterm infants. Study design: A prospective cohort study of preterm infants born before 29 weeks gestational age (GA) and admitted to the neonatal intensive care …
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Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… may have different gene expression and protein profiles. We first analyzed genome-wide microarray data from FXS lymphoblastoid cell, and found several immune gene sets are differentially expressed in FXS patients. We further reported that the cytokine profiles and cytokines activation profiles …
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Immunoprotective effects of lipopolysaccharide detoxification by a novel microbial-derived alkaline phosphatase
… lower levels of pro- and anti-inflammatory cytokine production as compared to iMPLA-treated cells. We then determined the serum cytokine profiles of piglets 2 days post-wean after being challenged with saline, MPLA, or LPS for four hours. Piglets i.p. injected with MPLA were more active and …
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Differential Interactions of Lipopolysaccharides with Lipid Bilayers: Applications for Pathogen Detection
… or in serum dramatically alters associated cytokine profiles. Our conclusions indicate that the biochemistry of amphiphilic molecules, like LPS, and their presentation, should always be considered when interfacing with physiological systems.
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A Comparative Study of the Pathology and Pathophysiology of Severe Malaria in a Non-Human Primate Model
… immunohistochemistry, cerebrospinal fluid cytokine profiles, transmission and scanning electron microscopy and atomic force microscopy of the disease in 45 adult rhesus macaques. The study further compared P. coatneyi with existing P. falciparum infected human material maintained at the …
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Proteomic Characterization of Eggshell Membranes and Their Effect on Poultry Physiology and Immunity
… to endotoxin challenges as indicated by splenic cytokine profiles of the chickens. In view of the need for alternatives to antibiotics in meat animal production, exploring the potential of egg byproducts as nutritional modulator of immunity during post hatch period appears logical.</p>
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
… and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at mucosal surfaces with roles in immune defence, tolerance and homeostasis. The key aims were to identify ILC3s within the renal tract (bladder, ureter and kidneys) and …
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The growth of murine breast cancer cells in dystrophic mice
… body composition, energy expenditure and plasma cytokine content between the C57BL/10ScSn-Dmdmdx/J (mdx) mouse model of DMD and C57BL/10ScSnJ (BL/10) control mice and to determine whether systemic alteration of the DGC (as observed in the mdx mouse) alters the growth of E0771 murine mammary …
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The role of tissue inflammation in Kenyan women with breast cancer
… and analysed on the Leica Aperio platform. Cytokine profiles of ER positive and Triple Negative BC were performed using microarray gene arrays and results validated with the ELISA platform. Multivariable polytomous logistic regression models were used to determine associations between BC …
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
… proliferation of intestinal cells. Suppressor of cytokine signalling 3 (SOCS3) is produced upon activation of the Janus kinase/Signal transducer and activator of transcription (Jak/Stat) pathway and this is an inducer of negative feedback inhibition and is implicated in regulation of intestinal …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… a variety of anti-inflammatory (T\(_H\)2) cytokines, such as interleukin-4 (IL-4), and pro-inflammatory (T\(_H\)1) cytokines, such as interferon-γ (IFN-γ). A decreased number of iNKT cells and defects in their capacity to produce T\(_H\)2 cytokines is associated with autoimmune diseases, …
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The premenstrual syndrome: characterisation, diagnosis and treatment
… serotonin levels and suppresses pro-inflammatory cytokine production. Following a systematic review which demonstrated that although calcium and continuous vitamin B6 administration confer some benefit for premenstrual symptoms, the evidence for most dietary supplements and herbal remedies …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… perform from collected stimulated saliva, and cytokine profiling from serum and gingival crevicular fluid (GCF) via Olink proteomics. Although high-risk PERK haplotypes did not show a significant correlation with clinical periodontitis or depression, carriers showed a higher prevalence of …
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