Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cytokine delivery"”.
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Layer-by-Layer Nanoparticles for Cytokine Delivery
… such as ovarian cancer (OC). The action of cytokines in the tumor microenvironment (TME) is key to regulating immune responses, but dose-limiting toxicities limit the application of cytokines in cancer therapy. One promising approach to improve treatment with cytokines are nanoparticles …
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Characterization of an IL-12-driven Anticancer Response, and the CD4+ CTL Population Incited, in a Murine Model of Leukaemia
… cancer and, as the quintessential Th1 polarizing cytokine, interleukin-12 (IL-12) holds much promise; however, optimal therapeutic protocols have yet to be developed and clinical results have fallen short of this promise. The in vivo IL-12 experiments described here highlight a characteristic of …
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Chondrogenesis of Stem/Progenitor Cells by Chemotaxis Using Novel Cell Homing Systems
… involves cell transplantation with or without cytokine delivery, biomaterial scaffolds, bioreactors, applied mechanical stimulation and altered oxygen tension. Despite its scientific merit, cell delivery faces drawbacks including scarce cell availability, donor site trauma, possible immune …
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Locally Administered Particle-Anchored Cytokines Safely Enhance Cancer Immunotherapy
… potent cancer immunotherapies, immunostimulatory cytokines have been shown to elicit anti-tumor immune responses in preclinical studies, but their clinical application is limited by severe immune-related adverse events upon systemic administration. None of the current delivery strategies can fully …