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Showing 1 to 20 of 53 for “"cytogenetics"”.
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Molecular cytogenetics and genetic characterisation of chromosomal rearrangements
In this thesis I report three related studies that utilise state-of-the-art technologies to investigate germline and somatic chromosomal rearrangements in humans. Firstly, 16 patients with cytogenetically detectable deletions of 3p25-p26 were analysed with high density single nucleotide …
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Investigation of the cytogenetics of marine and terrestrial gastropods
The investigation of the chromosomal variation in populations of the land snail Cepaea nemoralis (L.) marine snail Nucella lapillus (L.) is presented. The first study (Part 1) concerns the investigation of the karyotype of C. nemoralis in populations from a region of the Berkshire Downs (U.K.)in …
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Studies on the Genetics and Cytogenetics of Anopheles Quadrimaculatus
Made available in DSpace on 2014-12-04T22:46:18Z (GMT). No. of bitstreams: 1 6303245.pdf: 5320151 bytes, checksum: 5630ec967c88c1baf3d9e58e60688f91 (MD5) Previous issue date: 1962
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Cytogenetics and genome structure in genus Miscanthus, a potential source of bioenergy feedstocks
Miscanthus (subtribe Saccharinae, tribe Andropogoneae, family Poaceae) is a genus of temperate perennial C4 grasses. Accessions in the genus Miscanthus are potential crop candidates of lignocellulosic biomass for energy production, whose high biomass productivity is attractive as a biofuel …
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Bystander Effects Due To Neutrons, And Low-Dose Hyper-Radiosensitivity To Gamma Rays In Human Cells Using Cytogenetics
<p>Chapter 2:</p> <p>Micronuclei have been used extensively in studies as an easily-evaluated indicator of DNA damage but little is known about their association with other types of damage such as nucleoplasmic bridges and nuclear buds. Radiation-induced clastogenic events were evaluated via the …
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Molecular Signatures of gastric cancer: An integrated approach to molecular cytogenetics, whole genome copy number and transcriptome profiles
Signature chromosomal translocations in gastric cancer are poorly described. By integrating spectral karyotype and high-resolution genome copy number data, 45 recurrent translocations in 17 human gastric cancer cell lines were identified. Dissecting a simple rearrangement in SNU-1 cells using …
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Interim analysis of Acute Myeloid Leukaemia treated on the Red Cross Children's Hospital Rx 2071 (adapted from the MRC AML 15 protocol)
… Syndrome were excluded. Risk was assigned by cytogenetics. Good risk patients were those with t(8;21), t(16,16) and inv(16). Poor and standard risk included all other cytogenetics according to MRC-AML15. Data pertaining to toxicity was obtained from patient folders. Results: Thirty five …
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Cytogenetic and molecular analysis of follicular non-Hodkin's lymphoma
… be due to the method of detection used - usually cytogenetics alone or a combination of Southern blotting and polymerase chain amplification (PCR) of DNA extracted from malignant tissue. The shortcomings of each technique suggest that a combination of all three may best determine the true …
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Single nucleotide polymorphism array analysis in copy number variant detection: assessment of its feasibility in the diagnostic setting
… 5% of ID/DD can be identified with conventional cytogenetics. The Affymetrix® Cytoscan™ High Density (HD) Array (Affymetrix, Santa Clara, CA) containing over 2.4 million markers for copy number (CN) was used to detect genome-wide high resolution CN and single nucleotide polymorphisms (SNPs) in a …
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Utilization of fish for constitutional and acquired chromosomal abnormalities for diagnostic and prognostic purposes
… hybridization (FISH) is a useful molecular cytogenetics technique for counting chromosomes and identifying specific chromosomal sequences of interest. FISH probe targets include centromeres, single loci, subtelomeres, and telomeres, using DNA or peptide nucleic acid (PNA) probes. FISH probes …
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Cytogenetic abnormalities in Acute Myeloid Leukemia in Sweden. A population based study.
… in the elderly. The frequencies of unsuccessful cytogenetics (UC) and unperformed cytogenetics (UPC) were 2.1% and 2.0%, respectively. The early death rates differed between the cytogenetic subgroups (P=0.006) with the highest rates in patients with UC (14%) and UPC (12%) followed by high-risk …
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Isolation and Genomic Analysis of the Cetacean Y-chromosome
… species, using a combination of cell culture, cytogenetics and molecular approaches. Initially, the development of an efficient and repeatable methodology for obtaining a growing lymphocyte culture that facilitated the isolation of individual chromosomes is described. Flow karyotypic …
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A cytogenetic map for the genomic studies of the West Nile Virus vector Culex tarsalis
… chromosomes advances our understanding of Culex cytogenetics. Further comparative physical mapping of the three major mosquito genera will help us to understand the evolution of genus Culex better and to develop genome-based strategies for the vector control.
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
… been observed in 10 percent in AML with normal cytogenetics. In addition, internal tandem duplications (ITD) of FLT3 are frequently observed alterations in AML and coincide with mutations of C/EBPα. The effects of FLT3-ITD cooperation with C/EBPα mutations in AML are not fully understood. To …
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