Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"cytochromes P-450"”.
-
The fluroxene mediated degradation of cytochromes P-450
The degradation of cytochromes P-450 by fluroxene (2,2,2-trifluoroethyl vinyl ether) has been investigated. Fluroxene is shown to specifically degrade cytochromes P-450 in vivo and in vitro without affecting the levels of the other microsomal enzymes, cytochrome ~S a.nd NADPH-cytochrome~ reductase. …
-
Synthesis and Pulmonary Toxicity of Several 3-Furyl Ketones: Evidence for the Position of Metabolism by Cytochromes P-450
… Bioactivation of these heterocycles by pulmonary cytochromes P-450 is necessary for their toxicity, but the mechanism of this bioactivation is not clearly understood. Using a series of 3-furyl ketone congeners of perilla ketone, 1-(3-furyl)-4-methylpentan-1-one (2), it has been shown that the …
-
Catalytic site mutagenesis of cytochrome P450 6B1v1
Cytochromes P-450 form a large superfamily of heme-containing monooxygenases that are found in species ranging from bacteria to insects, plants, and mammals. In insects, P-450s have several functional roles, including growth, development, feeding, resistance to pesticides, and tolerance to plant …
-
Macromolecular recognition in the cytochrome P450(cam) enzyme system
The cytochrome P-450$\sb{\rm cam}$ reaction cycle is a complex set of coordinated chemical transformations requiring precise temporal and spatial control of reactivities. Cytochrome P-450$\sb{\rm cam}$ catalyzes the regio- and stereo-specific hydroxylation of camphor to form 5-exo-hydroxycamphor. …
-
Characterization of the cytochrome P-450IIC3 gene and 5' flanking region of P-450IIC1
Cytochromes P-450 are a superfamily of monooxygenases which metabolize a myriad of endogenous and exogenous substances. Cytochrome P-450 genes are differentially expressed in various tissues and differentially induced by many chemical agents. The rabbit cytochrome P-450IIC subfamily contains both …
-
The effect of dietary zinc on induction of cytochrome p-450 by phenobarbital or 3-methylcholanthrene in male Sprague-Dawley rats
… 40mg/kg had no effect on level of induction of cytochromes P-450 or b₅ by phenobarbital or 3-methylcholanthrene. Hepatic microsomes isolated from rats that received 40mg Zn⁺² were as effective in the biotransformation of aniline, aminopyrine, or p-nitroanisole as hepatic microsomes isolated from …
-
Purification and characterization of the hepatic microsomal monooxygenase system from the coastal marine fish Stenotomus chrysops
Three cytochrome P-450 forms were highly purified (8-12 nmol/mg) from the hepatic microsomes of the untreated coastal marine fish Stenotomus chrysops (scup) by detergent solubilization and column chromatography. Scup cytochromes P-450A, P-450B and P-450E (labeled in order of elution from the first …