Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"cytochrome P450s"”.
-
Characterization of Maize Cytochrome P450s
Messenger RNAs encoded by other maize P450 clones (CYP71C1, CYP51, CYP73A7, CYP73A6, CYP92A1, CYP95A1, and the ESTs 6c06b11 and 7c02c12) were also characterized with regard to their induction response to naphthalic anhydride and triasulfuron treatment. In addition, maize seedlings were also …
-
Investigation of cytochrome P450s in the biosynthesis of rice phytoalexins
… group of enzymes in diterpenoid biosynthesis are cytochromes P450 (CYPs) which catalyze various tailoring reactions on LRD olefins to produce bioactive diterpenoids. Intriguingly, two biosynthetic gene clusters (BGCs), composed of CYPs and upstream cyclases dedicated to LRD production, have been …
-
Isolation and characterization of cytochrome P450s from Papilio polyxenes and Papilio glaucus
Previous studies have isolated two cytochrome P450 monooxygenase cDNAs designated CYP6B1v1 and CYP6B1v2 from the oligophagous Papilio polyxenes. Baculovirus-mediated expression of these P450s demonstrated that both enzymes metabolize substantial amounts of linear furanocoumarins and low, if any, …
-
Breaking carbon-carbon bonds with cytochrome P450s from plants, animals, and bacteria
This Dissertation was approved for publication on 2022-04-19 at 13:48.
-
From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
Cytochrome P450s are an extremely versatile group on enzymes capable of metabolizing fatty acids, eicosanoids, sterols, vitamins, and xenobiotics. Those that metabolize fatty acids are of particular interest since some of the eicosanoid products are anti-inflammatory and have been shown to interact …
-
Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques. Development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research.
… Cellular membrane proteins, such as the cytochrome P450 enzyme superfamily (P450), have important roles in the physiology of the cell. P450s are important in metabolising endogenous molecules, as well as metabolising xenobiotic substances for detoxification and excretion. P450s are also …
-
Metabolism of omega-3 endocannabinoids by cytochrome P450s and the role of their metabolites in neurodegenerative diseases
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
-
Structure and Function of a Cytochrome P450 From Synechocystis Sp. PCC 6803
… ago it was thought that there were but a few cytochrome P450s and their functional landscape was relatively limited. We now know that there are over 6,000 P450 gene products, which display a variety of activities and provide interesting and crucial metabolic transformations. The search for …
-
Characterization of Monomeric Human Cytochrome P450 3A4 and Cytochrome P450 Reductase in Nanoscale Phospholipid Bilayer Discs
… either CYP3A4 or CYP3A4 and its redox partner, cytochrome P450 reductase, as a coincorporated complex are described and further characterized for substrate binding, rates of dithionite dependent reduction, NADPH utilization rates, and testosterone metabolic rates as a function of substrate …
-
GENETICS OF GROUP 14 HERBICIDE TOLERANCE IN LENTIL
… were detected; among the candidate genes were cytochrome P450s, glutathione-S-transferases, some stress-related genes and50 genes involve in plant growth and development. This suggests that a non-target site resistance mechanism in combination with plant regrowth is the main cause for the …
-
Engineering novel tandem reactions using organometallic catalysts and (metallo)enzymes
… with a par-ticular interest on combining cytochrome P450s and enoate reductases with organometallic cata-lysts. On the one hand, considerable efforts in transition-metal catalysis have culminated in prac-tical and efficient transformations such as isomerization, olefin metathesis, …
-
Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance
… assess the diversity and dietary regulation of cytochrome P450s (CYP), glutathione S-transferases (GST) and ABC transporters in the generalist marine gastropod Cyphoma gibbosum feeding on a variety of chemically defended gorgonian corals, and to identify those dietary natural products that act …
-
Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance
… assess the diversity and dietary regulation of cytochrome P450s (CYP), glutathione S-transferases (GST) and ABC transporters in the generalist marine gastropod Cyphoma gibbosum feeding on a variety of chemically defended gorgonian corals, and to identify those dietary natural products that act …
-
THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… investigate the expression of several candidate Cytochrome P450s (CYPs) related to TCE metabolism. We observed a significant induction of multiple CYP2 family members in the developing heart after low dose TCE exposure. Together, these data suggest cardio-specificity of TCE as a teratogen and may …
-
Non-target-site resistance to ALS inhibitors in waterhemp
… of ALS-inhibitors. Thirdly, malathion, a cytochrome P450-inhibiting pesticide, was incorporated with ALS-inhibitor application to unveil the possible mechanism of resistance. Based on the results obtained, it was concluded that both target-site-mutation-based and metabolism-based ALS …
-
Regulatory mechanisms involved in the control of <i>CYP6M2</i> gene in insecticide resistant <i>Anopheles gambiae</i> (Diptera: culicidae)
Cytochrome P450s, including <i>CYP6M2</i> gene, are involved in the detoxification of permethrin. Some of these genes are regulated by <i>CnCC / dKeap</i> 1 and Spineless / <i>Tango </i>in <i>Drosophila melanogaster</i>. This mechanism is yet to be identified in <i>Anopheles gambiae</i>. Thus, we …
-
Bioremediation of Trichloroethylene: Analysis of the Plant Gene Response to TCE and Characterization of a Novel TCE-Degrading Endophyte
… was that certain detoxification genes such as cytochrome P450s (CYP), glutathione-S-transferases (GST), glycosyltransferases (UGT), and ATP-binding cassette (ABC) transporters are involved in TCE metabolism in poplar. The study found that poplar trees do have a genetic response to TCE and that …
-
Human Genetics, Psychotropic Drugs, and Acts of Violence
… are primarily responsible for their metabolism (cytochrome P450s) could cause these reactions. Given that acts of violence could be medication-induced, the role of the rate of drug metabolism is discussed. Genetic testing of certain CYP450s could be helpful in preventing the emergence of acts of …
-
Molecular Definition of Cytochrome P450 -Mediated Multiple Resistance in Helicoverpa Zea
… and biochemical assays demonstrated that cytochrome P450s are responsible for the documented cross-resistance and that metabolism of these two compounds is mediated by at least one P450. Closely related P450s in the CYP6B subfamily (CYP6B8, CYP6B9, CYP6B27, CYP6B28) are cloned from this …
-
Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1
… of electrons from its obligate redox partner, cytochrome P450 reductase (CPR). Here the triphasic kinetics of the potentially rate-limiting first electron transfer from CPR to CYP2J2 are reported. These rates are similar to previously reported rates of other CYPs and show differences with …
Page 1 of 3