Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"cytochrome P450 2J2"”.
-
Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
Cytochrome P450 2J2 (CYP2J2) is membrane bound enzyme that is highly expressed in the cardiovascular system and brain where it mediates the metabolism of polyunsaturated fatty acids into oxygenated bioactive metabolites. This enzyme is most well-known for the conversion of arachidonic acid into …
-
Development of label-free colorimetric plasmonic sensor for biomedical applications
… demonstration of detection of drug bindings with cytochrome P450-2J2 using the nanoLCA device. Cytochrome P450-2J2 is the most common enzyme found in human heart and it is involved in drug metabolism. All bio-molecular detections are done using nanoLCA based on the shift in resonance peak …
-
Computational investigation of membrane proteins across species and functional classes
… I then explore substrate binding in human cytochrome P450 2J2 using molecular docking, MD simulations, and free energy perturbation calculations, elucidating structural determinants governing regioselective cannabinoid metabolism. Next, I examine lipid-dependent stabilization of the …
-
From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
Cytochrome P450s are an extremely versatile group on enzymes capable of metabolizing fatty acids, eicosanoids, sterols, vitamins, and xenobiotics. Those that metabolize fatty acids are of particular interest since some of the eicosanoid products are anti-inflammatory and have been shown to interact …