Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"cytochrome P450 1A1"”.
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In search of human cytochrome P450 1A1 enzyme inhibitor
Human cytochrome P450 1 (CYP1) family consists of three members; they are CYP1A1, CYP1A2 and CYP1B1. The mRNAs of CYP1A1 and CYP1B1 genes are known to be expressed in extra-hepatic tissues while that of the CYP1A2 gene is found in the liver amongst other tissues. Under normal circumstances, rarely …
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
… susceptibility of cetaceans to such exposures. Cytochrome P450 1A1 (CYP1A1) induction by planar halogenated aromatic hydrocarbons, including certain polychlorinated biphenyls (PCBs), has been correlated with toxic effects in rodents. CYP1A1 expression was measured in multiple organs from beluga …
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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in Delphinid cetaceans
… toxic mechanism may include the induction of cytochrome P450 enzymes in the integument and liver, which could enhance the biotransformation of PCBs to hydroxylated metabolites (OH-PCBs). OH-PCBs may then interfere with thyroid hormone dependent neurodevelopment. The goals of these studies were …
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Vliv cytochromu b5 na enzymovou kinetiku hydroxylace Sudanu I lidským cytochromem P450 1A1
Cytochromes P450 are the major xenobiotics converting enzymes. They are classified as mixed function monooxygenases (MFO). Isoform 1A1 is a extrahepatic form found mainly in the lung and other tissues. It is strongly induced by polycyclic aromatic hydrocarbons and their derivatives via the Ah …
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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in delphinid cetaceans
… toxic mechanism may include the induction of cytochrome P450 enzymes in the integument and liver, which could enhance the biotransformation of PCBs to hydroxylated metabolites (OH-PCBs). OH-PCBs may then interfere with thyroid hormone dependent neurodevelopment. The goals of these studies were …
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Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
… (fc: 2.01±0.28), HSPA1B (fc: 2.20±0.35), and cytochrome P450 1A1 (CYP1A1) (fc: 3.24±1.06), matching NGS data trends. Extending CA venom stimulation to 8 hours significantly increased the gene expression of metallothionein 1X (MT1X, fc: 5.64±1.34) and peroredoxin-4 (PRDX4, fc: 3.29±0.43) …
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Detection of Biological Effects of Environmental Pollutants of the Kafue River on the Kafue Lechwe (KOBUS LECHE KAFUENESIS)by Characterization of Selected Biomarkers
… study was aimed at assessing the potential of Cytochrome P450 1A1 (CYP 1A1), Cytochrome P450 3A (CYP 3A) and Metallothionein1 (MT 1) as biomarkers in the Kafue lechwe in response to pollutants in the Kafue river. Kafue lechwe liver samples from Lochnivar GMA (n=23) and Blue Lagoon GMA (n=15) …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… of the phase I detoxification enzyme cytochrome P450 (CYP) 1A. Broccoli inhibited growth of human prostate and ovarian cancer cells via induction of apoptosis, but this was not due to formation of 2-methoxyestradiol. Compared to the purified glucosinolate breakdown products I3C and …