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Showing 1 to 20 of 287 for “"cytochrome P450"”.
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Characterization of Monomeric Human Cytochrome P450 3A4 and Cytochrome P450 Reductase in Nanoscale Phospholipid Bilayer Discs
… either CYP3A4 or CYP3A4 and its redox partner, cytochrome P450 reductase, as a coincorporated complex are described and further characterized for substrate binding, rates of dithionite dependent reduction, NADPH utilization rates, and testosterone metabolic rates as a function of substrate …
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A Thermostable Cytochrome P450 From Sulfolobus Solfataricus
… in the active site that are important in the P450 dioxygen scission reaction. CYP119 is found to display a mobile F-G helix and loop region that undergoes a significant conformational change upon binding of medium and large ligands and may reflect a natural motion independent of ligand …
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Catalytic site mutagenesis of cytochrome P450 6B1v1
Cytochromes P-450 form a large superfamily of heme-containing monooxygenases that are found in species ranging from bacteria to insects, plants, and mammals. In insects, P-450s have several functional roles, including growth, development, feeding, resistance to pesticides, and tolerance to plant …
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Cytochrome P450 whole cell biohydroxylation of alkanes
… pathways to produce value added chemicals. Cytochrome P450 (CYP) monooxygenases such as CYP153A6 have previously shown excellent 95% selectivity for hydroxylation at the terminal carbon on n-octane and CYP153A13 has shown promising activity on n-octane and n-decane. In the present study, …
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Moessbauer Studies of Cytochrome-P450 From Pseudomonas Putida
Made available in DSpace on 2015-05-12T22:39:07Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7412185.PDF: 4019834 bytes, checksum: e4e5fb11b5fca0d3a3f6ddfc3371bfcb (MD5) Previous issue date: 1973
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In search of human cytochrome P450 1A1 enzyme inhibitor
Human cytochrome P450 1 (CYP1) family consists of three members; they are CYP1A1, CYP1A2 and CYP1B1. The mRNAs of CYP1A1 and CYP1B1 genes are known to be expressed in extra-hepatic tissues while that of the CYP1A2 gene is found in the liver amongst other tissues. Under normal circumstances, rarely …
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Global deconvolution of heterotropic cooperativity in cytochrome P450 3A4
Cytochrome P450 3A4 (CYP3A4) plays a central role in xenobiotic metabolism, and is of critical importance to both human health and the pharmaceutical industry. Its ability to interact with multiple molecules of the same substrate, or multiple substrates, leads to complex non-Michaelis kinetics, …
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Macromolecular recognition in the cytochrome P450(cam) enzyme system
The cytochrome P-450$\sb{\rm cam}$ reaction cycle is a complex set of coordinated chemical transformations requiring precise temporal and spatial control of reactivities. Cytochrome P-450$\sb{\rm cam}$ catalyzes the regio- and stereo-specific hydroxylation of camphor to form 5-exo-hydroxycamphor. …
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BIOACTIVATION OF NATURAL DIETARY PRODRUGS BY SPECIFIC CYTOCHROME P450 ENZYMES
Tumour specific cytochrome P450 enzymes (CYPs) have recently been established as a novel target in anticancer drug discovery. The enzymes are used to activate nontoxic prodrugs with latent activity. Thus, the combination of tumour specific CYPs as ‘rescue enzymes’ with a suitable substrate provides …
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Characterisation of mammalian cytochrome P450 enzymes by their metabolic activities.
… and thereby characterise human liver microsomal cytochromes P450 responsible for the in vitro transformation of the B-carbolines, harmine and harman. Comparative studies were also carried out with rat liver microsomal P450s, where the effects of induction on the metabolism of harmine were …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with …
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… <p>Metabolic activation of NNK depends upon cytochrome P450 enzymes (GYP). A second study looked at O-dealkylation of the substrates benzyloxyresorufin (BROD), ethoxyresorufin (EROD) and methoxyresorufin (MROD) linked to CYP2B1,2C6 and 1A2, respectively. Pycnogenol significantly inhibited …
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Resin Detoxification in Dendroctonus ponderosae: Functional Characterizations of Cytochrome P450 Proteins
… beneath the tree bark to reproduce. MPB use cytochrome P450 enzymes to both detoxify toxic monoterpene compounds present in tree resin as well as synthesize the pheromones used during tree invasion, suggesting an evolutionary link between the P450 proteins involved in the two processes. This …
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Genetic evaluation of cytochrome P450 expression in smoking and nonsmoking women
… Of these, CYP3A3/4 is the most abundant P450 isoform and is responsible for metabolizing estrogen as well as a variety of therapeutic agents, whereas CYP3A7, the fetal liver form, is involved in the biosynthesis of estriol. The goal of this study was to evaluate the expression of these …
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Human Cytochrome P450 2E1: Functional Comparison to Cytochrome 2A13 and 2A6
The cytochrome P450 (CYP) superfamily of enzymes plays the predominant role in human phase I xenobiotic metabolism. The CYP2 family, in particular, is known for it extensive Phase I metabolism of a majority of the xenobiotic compounds [1]. The goal of this project is to determine the structural …
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The modulation of cytochrome P450 activities by their membrane lipid environment
Cytochrome P450 (GYP) are a family of membrane-bound enzymes which form a component of the mixed function oxidase (MFO) system and are involved in the metabolism of many endogenous and exogenous compounds and, as such, play key roles in many physiological, pharmacological and toxicological …
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Molecular Definition of Cytochrome P450 -Mediated Multiple Resistance in Helicoverpa Zea
… and biochemical assays demonstrated that cytochrome P450s are responsible for the documented cross-resistance and that metabolism of these two compounds is mediated by at least one P450. Closely related P450s in the CYP6B subfamily (CYP6B8, CYP6B9, CYP6B27, CYP6B28) are cloned from this …
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Structural Biology of Cytochrome P450 Monooxygenases in Arabidopsis Thaliana Phenylpropanoid Pathway
Plant genomes are rich in cytochrome P450 monooxygenase sequences with 246 full-length genes found in the Arabidopsis thaliana genome. Unlike other enzymes that catalyze substrate modifications, P450s catalyze the activation of oxygen, which then reacts with the nearest substrate atom. Among the …
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