Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"cytoarchitecture"”.
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Cortical structure: Linking MRI and cytoarchitecture
… of linking microscale post mortem cortical cytoarchitecture with millimeter-scale measures of cortical anatomy accessible through in vivo MRI. Chapter 1 introduces the problem and previous work done to address it. The following two chapters apply classical atlases of cortical …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
Glutamate (Glu) is the primary excitatory neurotransmitter in the mammalian brain and a key metabolic intermediate in neurons and astrocytes. Shifts in glutamatergic biology can both reflect and drive changes in circuit excitability, synaptic structure, glial function, and cellular metabolism, …
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The development, cytoarchitecture, and circuitry of the ventral lateral geniculate nucleus
… non‐image‐forming vision and its neurochemistry, cytoarchitecture, and retinothalamic connectivity all remain unresolved, raising fundamental questions of its role within the visual system. Here, we sought to shed light on these important questions by studying the cellular and extracellular …
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Interaction between form and fate during human neural development
… features. Morphology alone can predict organoid cytoarchitecture and transcriptional proximity to the *in vivo* developing brain. Organoids with complex morphology display more and larger ventricles with thicker progenitor layer. They better resemble the transcriptome of foetal brain. Organoids …
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Identification, Characterization and Mechanism of the Estrogen Regulation of the Gene Encoding the Sodium /Hydrogen Exchanger -Regulatory Factor (nhe-Rf)
… on cell signaling, fluid exchange and cell cytoarchitecture."
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Cells, circuits, and development of the mouse lateral geniculate nucleus
… (IGL). Previous studies have characterized the cytoarchitecture and circuitry of dLGN, which is crucial for classical image-forming vision. However, the molecular resolution of subtypes and the connection between subtypes of retinal ganglion cells with those cell types in dLGN remains …
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MRI for gray matter: statistical modelling for in-vivo application and histological validation of dMRI
… to capture the biological features of underlying cytoarchitecture and identify the dMRI measures that best reflect underlying gray matter cytoarchitectural properties. Investigation of the contribution of underlying cytoarchitecture (cellular organization) to dMRI measures in gray matter provides …
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A Microfabricated Bioimpedance Sensor with Enhanced Sensitivity for Early Breast Cancer Detection
… cancer cells by selectively modifying their cytoarchitecture.
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Identification of Cell Biomechanical Signatures Using Three Dimensional Isotropic Microstructures
… significantly altered the cells morphology, cytoarchitecture and adhesion pattern inside the 3-D microstructures. Third generation of silicon substrates was developed for comprehensive analysis on behavior of MDA-MB-231 and MCF10A cells in a co-culture system in response to SAHA drug. …
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Mining the Medulloblastoma Genome and Transcriptome
… on the establishment of the normal cerebellar cytoarchitecture, identifying a physiological glutamate gradient with critical implications to both cerebellar development and disease. This thesis stresses the importance of interrogating medulloblastoma in a subgroup-specific manner. Our findings …
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Composite Diaphragm Inflation: A Method for Probing the Rheological Functions of Cell -Cell Anchoring Junctions and Cytoskeletal Networks Within a Living Normal Human Epidermal Keratinocyte Sheet
… transform morphological observations of NHEK cytoarchitecture into well-posed boundary value problems amenable to mechanical experimentation and hypothesis testing.
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… is the principal determinant of the final brain cytoarchitecture. However, we have only limited knowledge about the migratory pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing forebrain. I …
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
… of two neuronal subtypes that have distinct cytoarchitecture and intrinsic properties; the latter could influence their role in arousal and motor activity. I next examined the actions of cholinergic agonists on rat parafascicular nucleus neurons. The muscarinic receptor agonist, …
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BRAIN ORGANOIDS AS MODELLING CONDUITS OF HUMAN NEURODIVERSITY: ADVANCED COMPUTATIONAL APPROACHES TO SINGLE CELL TRANSCRIPTOMICS
… and of animal models in recapitulating CNS cytoarchitecture. The advent of single cell (SC) RNA sequencing (scRNA-seq) offered the possibility to pair BOs morpho-functional complexity to its molecular characterization. Despite the recent ameliorations of BOs, they are facing two main …
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Morphogenetic Principles of Brain Organisation in Health and Disease
… context for the new methods presented, from cytoarchitecture to gene expression to connectomes. Chapters 2-4 introduce a new method, “Morphometric Similarity Mapping”, which captures the brain organisation of an individual by mapping the relationships of multiple features of the cerebral …
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Multimaterial multifunctional fibers for biomedical applications
… and bioimpedance sensing. Understanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires the development of improved miniaturized neural interfaces that integrate into brain tissue …
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Examining the role of the anterior and posterior orbitofrontal cortex in emotional regulation in the common marmoset (Callithrix jacchus)
… the central orbitofrontal cortex. Evidence from cytoarchitecture, connectivity and function supports the idea that the two sub-regions may have distinct functional contributions. Overall, the purpose of the research in this thesis was to explore the possible contributions of the anterior and …
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Scalable Subcellular Resolution Mapping of the Human Brain
… (AD) pathology at multiple scales from overall cytoarchitecture to individual synapses. Finally, we demonstrated, for the first time, the feasibility of scalable neural connectivity mapping in the human brains, establishing a path for probing brain connectivity and its alterations in diseases.
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Characterizing Medial Temporal Lobe Neurodegeneration Due To Tau Pathology In Alzheimer's Disease Using Postmortem Imaging
… derived from serial histology on the basis of cytoarchitecture. Leveraging the developed registration frameworks and serial histology datasets, I investigate the relationship between tau pathology and regional MTL cortical thickness, while correcting for age and the presence of co-pathologies, …
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