Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cystogenesis"”.
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Leveraging cellular models of polycystic kidney disease for mechanistic discovery and therapeutic development
… is sufficient to drastically reduce PKD cystogenesis. In our PKD tubular epithelial cell model, we find dynamic regulation of PC1 that is dependent on both PC2 and confluence. Using RNA-sequencing, we identify instability of primary cilia, where the polycystins co-localize, that …
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Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
… of the mechanisms that lead to renal cystogenesis.
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… its hydrolysis. cAMP may play a role in cystogenesis by stimulating fluid secretion and cell proliferation. PDE4C is transcriptionally activated by HNF-1Beta and regulates cAMP levels in mIMCD3 renal epithelial cells. Antibody staining showed that PDE4C is localized in the primary cilium …
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The role of Rnd3 in kidney morphogenesis and function
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an adult-onset, multi-systemic disorder, which affects ~12.5 million people worldwide. ADPKD is characterised by progressive kidney enlargement caused by continuous growth of cysts, alongside extra-renal phenotypes. ADPKD is caused by …