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Showing 1 to 4 of 4 for “"cysteinyl leukotriene receptor 1"”.
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
Cysteinyl leukotrienes (cysLTs) are potent inflammatory lipid mediators that play a major role in the pathophysiology of inflammatory diseases. They signal primarily through cysteinyl leukotriene receptor-1 (cysLTR1) and have been reported to drive Th2 immune responses. Initiation and amplification …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… developing alternate host- derived therapies. Leukotrienes (LTs), produced by macrophages and other phagocytic cells including neutrophils, mast cells and dendritic cells during arachidonic acid metabolism, are hypothesized to induce a protective response during cutaneous leishmaniasis. …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
BACKGROUND: Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus …
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Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4
… are still not completely understood. Cysteinyl leukotrienes (CysLTs) play important roles in eosinophilic airway inflammation of AIA via CysLTR1-mediated mechanism. Leukotriene modifier MK-571, a selective CysLTR1 antagonist, is widely used in the management of asthma. We selected …