Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"cysteine biosynthesis"”.
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Antibiotic Drug Discovery Targeting Bacterial Metabolism
… The mechanisms of resistance to folate biosynthesis inhibitors in Staphylococcus aureus were explored from a genetic, biological, biochemical, and structural basis. Unexpected roles in resistance and fitness were attributed to various mutations in the sulfonamide target dihydropteroate …
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The biochemistry and phylogeny of CysE: An antimicrobial target
… the potential of targeting the de novo cysteine biosynthetic enzyme, serine acetyltransferase, from N. gonorrhoeae (NgCysE) for new antimicrobials. In this thesis, we present the kinetic and structural characterisation of NgCysE. NgCysE has serine acetyltransferase activity and is …
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Investigation of O-acetylserine sulfhydrylase enzymes from bacterial pathogens as potential drug targets
… mechanisms. A key enzyme in the de novo biosynthesis of L-cysteine, O-acetylserine sulfhydrylase (CysK), represents a promising target for antimicrobial intervention due to its essential role in sulfur metabolism and bacterial survival. This thesis presents the first comprehensive …