Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"cystatin C"”.
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… the role of a lysosomal enzyme inhibitor, Cystatin C (CysC), in an animal model of multiple sclerosis (MS), called experimental allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) …
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Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
… strategies for their treatment. In hereditary cystatin C amyloid angiopathy (HCCAA), a cystatin C variant is deposited in arterial walls and causes brain hemorrhage in young adults. Although carriers of the cystatin C variant may be easily identified by genetic testing, no treatments are …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. Cystatin C has been considered to excert its enzyme inhibiting functions extracellularly, as a defense …
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Domain swapping as a molecular mechanism in amyloidosis
… deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion proteins have been …
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Low molecular mass proteins as markers for renal function and dialysis efficiency
… a blood sample and measure the concentration of cystatin C is presented. This equation is the first one working both for adults and children. To establish an equation working at all laboratories, primary and secondary reference preparations for cystatin C were developed. The secondary reference …
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The relationship between reduced renal function and cardiovascular disease
… CVD, stroke and CVD death. In Study 2 we tested cystatin C and compared it to eGFR estimated with the MDRD, CKD-EPI 2009 and the CKD-EPI-comb (combining creatinine and cystatin C) formulas as predictors of CVD, CVD mortality and all-cause mortality. In study 3 we investigated whether or not there …
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Importance of renal function in cardiac surgery
… the study, AKI was evaluated by the changes of s-cystatin C at the third postoperative day from baseline. No protective effect against AKI by EPO could be shown. In the fourth paper the predictive value for mortality of s-creatinine and s-cystatin C and their eGFR were evaluated at different time …
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Aspects of retransfusion of shed blood in cardiac surgery
… intervention and for the prediction of outcome. Cystatin C has been suggested as a more sensitive marker of glomerular filtration rate (GFR) than creatinine, which today is the most commonly used marker of GFR. In study I and II, we studied the distribution and the kinetics of lipid microemboli …
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An analysis of the mechanisms of acute kidney injury and novel biomarkers
… themselves. Some of these new biomarkers include cystatin C, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase associated lipocalin (NGAL). This study will investigate how the properties of these new biomarkers are superior when compared to those of serum creatinine in early detection of …
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Cistatina-C como marcador de función renal y riesgo vascular en población general
… 1. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002; 40: 221-6. 2. Köttgen A, Selvia E, Stevens LA, Levey AS, Lente VF, Coresh J. Serum cystatin C in the United States: The Third National …
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The use of liquid-chromatography mass spectrometry for the absolute quantitation for bio-analytes: fro small molecular mass compounds towards larger molecular mass proteins
… also for the larger molecular mass protein cystatin C was mass spectrometry investigated for its absolute quantitation. This, by means of marker peptides. In this way, the larger molecular mass compound is diverted into a smaller molecular mass compound.
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The Effect of Preeclampsia on Renal Function: Cross-Sectional Studies of Postpartum Preeclamptics and Women Who Were Destined to Develop Preeclampsia
… were or were not destined to develop PE, plasma cystatin C concentration was analysed. After phosphate loading, women with a history of PE had significantly elevated serum phosphate at both 1- and 2-hour, while controls had higher urine phosphate:urine creatinine excretion ratio at 1-hour than …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (±8.35) years and the median CD4+ T-cell count was 498 (IQR: 389 – 651) cells/μL. Biomarker concentrations between groups did not differ at baseline. …
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The Relationship of Inflammatory Markers to Cognitive Function in a Population-Based Sample
… intake, diabetes mellitus, waist circumference, Cystatin C) and APOE 4 as mediators of cognitive function. METHOD AND RESULTS: Participants include 1904 individuals with CRP, IL-18, MCP-1, and Lp-PLA2, vascular risk factor and APOE 4 data collected as part of the Dallas Heart Study I initiated in …
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Novel Astrocyte-Specific Transgenic Mice Identify Distinct Populations of Transient Amplifying Progenitor Cells And Long-Lived Neural Stem Cells In the Subgranular Zone of the Adult Mouse Brain
… heterogeneity. Through a careful screen, cystatin C (CstC) and phospholipase A2 Group VII (PLA2G7) were identified as astrocyte specific molecular markers. To study the role of these genes in astrocyte biology, inducible CreERT2 mice were generated. Using the CstC-CreERT2 and …
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Engineering scFv Antibodies for Point-of-Care Diagnostics
… kidney dysfunction in neonates. Changes in Cystatin C (CysC) serum levels are physiologically time effective, but current testing methods precludes the usefulness of CysC as a fast responder. This thesis explores the design of bio-reagents that could be used in the development of a ‘faster’ …
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Population-based prediction of atrial fibrillation
… MR-proADM, NT-proBNP, copeptin, CRP and cystatin c) were measured in a random subcohort (n=6104).Results: Case validity of AF diagnoses in national registers was estimated to be high, 95-97%. A substantial proportion of population risk was conferred by conventional risk factors …
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MANAGING DRUG USE IN THE ELDERLY. General practitioners’ adherence to guidelines and patients’ conceptions of medication
… function, estimated from s-creatinine and s-cystatin C. (Paper III) Data about GPs adherence to guidelines was collected from the medical records of patients aged ≥ 65 with a cardiovascular diagnosis. Local education was organized, followed by repeated measurements. Results: The knowledge …
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THE VASOPRESSIN SYSTEM IN DIABETES MELLITUS, OBESITY AND THE METABOLIC SYNDROME
… for clinical and anthropometric risk factors, cystatin C, and C-reactive protein, increasing copeptin quartile (lowest quartile as reference) was associated with prevalent DM (Ptrend=0.04). Furthermore, copeptin quartile was after adjustment for age, sex, insulin and diabetes mellitus …
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