Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"cystatin"”.
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… the role of a lysosomal enzyme inhibitor, Cystatin C (CysC), in an animal model of multiple sclerosis (MS), called experimental allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) …
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Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
… strategies for their treatment. In hereditary cystatin C amyloid angiopathy (HCCAA), a cystatin C variant is deposited in arterial walls and causes brain hemorrhage in young adults. Although carriers of the cystatin C variant may be easily identified by genetic testing, no treatments are …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
Cystatin C is a cysteine protease inhibitor, aimed for secretion, as it is produced with a signal peptide. Its target enzymes are thought to be the lysosomal cysteine cathepsins and legumain. Cystatin C has been considered to excert its enzyme inhibiting functions extracellularly, as a defense …
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Domain swapping as a molecular mechanism in amyloidosis
… deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion proteins have been …
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Low molecular mass proteins as markers for renal function and dialysis efficiency
… a blood sample and measure the concentration of cystatin C is presented. This equation is the first one working both for adults and children. To establish an equation working at all laboratories, primary and secondary reference preparations for cystatin C were developed. The secondary reference …
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The relationship between reduced renal function and cardiovascular disease
… CVD, stroke and CVD death. In Study 2 we tested cystatin C and compared it to eGFR estimated with the MDRD, CKD-EPI 2009 and the CKD-EPI-comb (combining creatinine and cystatin C) formulas as predictors of CVD, CVD mortality and all-cause mortality. In study 3 we investigated whether or not there …
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An Insight Into the Microbial Diversity and Expression of Cysteine Protease Inhibitors (Cystatin) in <i>Rickettsia parkeri</i> Infected <i>Amblyomma maculatum</i>
… parkeri</em>. On the other side, we observed cystatins temporal transcriptional expression in <em>A. maculatum</em>across the blood meal cycle and our finding suggested their importance during blood feeding. Further, we saw <em>R. parkeri</em> differentially regulates gene expressions of …
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Cloning and expression of a modified oryzacystatin inhibitor gene and an investigation of its inhibitory capabilities
… in order to improve their effectiveness. Because cystatins have already been isolated from plants. they provide a good starting point for developing modifications which may improve their function as biocontrol agents. The purpose of this project, therefore, was to design a potentially improved …
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Importance of renal function in cardiac surgery
… the study, AKI was evaluated by the changes of s-cystatin C at the third postoperative day from baseline. No protective effect against AKI by EPO could be shown. In the fourth paper the predictive value for mortality of s-creatinine and s-cystatin C and their eGFR were evaluated at different time …
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Zur molekularen Topologie der Bindung natürlicher und rekombinanter Varianten von Alpha 2 -HS-Glycoprotein-Feturin an Hydroxylapatit
… relations of protein domains of the cystatin superfamily. Since no structural data of these cystatin-like domains were available, models were generated by comparative structure modelling. The model of AHSG domain D1 shows an aminoterminal alpha-helix and a bent four-stranded …
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Aspects of retransfusion of shed blood in cardiac surgery
… intervention and for the prediction of outcome. Cystatin C has been suggested as a more sensitive marker of glomerular filtration rate (GFR) than creatinine, which today is the most commonly used marker of GFR. In study I and II, we studied the distribution and the kinetics of lipid microemboli …
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An analysis of the mechanisms of acute kidney injury and novel biomarkers
… themselves. Some of these new biomarkers include cystatin C, kidney injury molecule-1 (KIM-1), and neutrophil gelatinase associated lipocalin (NGAL). This study will investigate how the properties of these new biomarkers are superior when compared to those of serum creatinine in early detection of …
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Cistatina-C como marcador de función renal y riesgo vascular en población general
… 1. Dharnidharka VR, Kwon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002; 40: 221-6. 2. Köttgen A, Selvia E, Stevens LA, Levey AS, Lente VF, Coresh J. Serum cystatin C in the United States: The Third National …
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The use of liquid-chromatography mass spectrometry for the absolute quantitation for bio-analytes: fro small molecular mass compounds towards larger molecular mass proteins
… also for the larger molecular mass protein cystatin C was mass spectrometry investigated for its absolute quantitation. This, by means of marker peptides. In this way, the larger molecular mass compound is diverted into a smaller molecular mass compound.
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Cistatinas de cebada: proteínas de defensa contra artrópodos
… y evitar la adaptación de los mismos. SUMMARY Cystatins are a group of proteins identified in animals, plants and microorganisms that inhibit cysteine proteases C1A from the papain family. Plant cystatins or phytocystatins have an endogenous function related with the protein turnover and the …
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An integrated top-down and bottom-up proteomic platform to reveal potential salivary biomarkers of the rare disorders SAPHO syndrome, Wilson’s disease and Hereditary angioedema
… syndrome revealed a significant decrease of cystatins, histatins, and aPRPs, which are involved in the protection against infections, suggesting a reduced ability of these subjects to contrast bacteria colonization, in particular P. acnes which is a possible trigger of this disease. In …
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Cloning and targeted deletion of the mouse histidine rich glycoprotein gene and functional characterization of HRG in mice
… similarity, it is classified to belong to the cystatin superfamily like fetuin-A, fetuin-B and kininogen. Mature HRG circulates in blood at relatively high concentrations of up to 150 mg/l (~2 µM). HRG is exclusively synthesized in the liver, but it is stored in platelets and megakaryocytes …
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