Global ETD Search
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Showing 1 to 2 of 2 for “"cystathionine gamma-lyase"”.
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The traditionally protective cystathionine gamma-lyase/hydrogen sulfide pathway contributes to pathological retinal neovascularization in oxygen-induced retinopathy
CSE is a key enzyme involved in the production of H2S and glutathione. CSE has been shown to protect against oxidative stress, attenuate ischemia/reperfusion injury, and promote angiogenesis, functions which are typically beneficial in ischemic tissue. However, retinal ischemia can cause …
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The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth
… reduction in cell viability. The expression of cystathionine gamma-lyase (a major H2S-generating enzyme) was lower but ALDH was higher in mouse liver cancer stem cells (Dt81Hepa1-6) in comparison with their parental cells (Hepa1-6), and H2S was able to inhibit liver cancer stem cell adhesion. In …