Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"cystathionine"”.
-
Synthesis of Inhibitors of Cystathionine β-Synthase
… of H2S is required to maintain homeostasis. Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are the two main PLP-dependent enzymes that contribute to H2S metabolism through generation from L-cysteine. A recent study has discovered a link between CBS-derived H2S and tumor growth …
-
Cloning and Overexpression of Yeast Cystathionine γ-Lyase
Cystathionine γ-lyase (CGL) is a protein involved in the conversion of methionine to cysteine as part of the trans-sulfuration pathway. Inactivation of the enzyme, possibly by oxidation of reactive site residues, has been linked to cataractogenesis. This research isolated the cystathionine γ-lyase …
-
Enhanced methylglyoxal formation in cystathionine γ-lyase knockout mice
… of the protein and activity level of cystathionine γ-lyase (CSE), the main H₂S-generating enzyme in the vasculature. Moreover, H₂S can induce the inhibition of MG-generated ROS production in a concentration-dependent manner in A-10 cells. In 6-22 week-old CSE knockout male mice …
-
Upregulation of Cystathionine-β-synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Cystathionine β synthase (CBS) is a hydrogen sulfide producing enzyme that catalyzes the first step of the transsulfuration pathway converting homocysteine to cystathionine. CBS and the subsequent production of H2S are selectively upregulated in human colon cancer compared to patient matched normal …
-
Investigation of cystathionine β-synthase as a cause of mild hyperhomocysteinaemia in patients with peripheral vascular disease
… the enzymes involved in methionine metabolism. Cystathionine β-synthase (CBS) is the most common genetic cause of homocystinuria, the severe form of the disease. The incidence of CBS deficiency in a group of 12 young patients of varied ethnic origin, who had peripheral vascular disease (PVD) …
-
The traditionally protective cystathionine gamma-lyase/hydrogen sulfide pathway contributes to pathological retinal neovascularization in oxygen-induced retinopathy
CSE is a key enzyme involved in the production of H2S and glutathione. CSE has been shown to protect against oxidative stress, attenuate ischemia/reperfusion injury, and promote angiogenesis, functions which are typically beneficial in ischemic tissue. However, retinal ischemia can cause …
-
The Redox and Systems Biology of Ergothioneine Biosynthesis in Aspergillus fumigatus
… the reciprocal differential abundance of cystathionine γ-synthase and β-lyase, respectively, influenced cystathionine availability to affect EGT biosynthesis. Quantitative proteomic analysis also identified VipC (AFUA_8G01930), a putative methyltransferase which may be involved in the A. …
-
The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth
… reduction in cell viability. The expression of cystathionine gamma-lyase (a major H2S-generating enzyme) was lower but ALDH was higher in mouse liver cancer stem cells (Dt81Hepa1-6) in comparison with their parental cells (Hepa1-6), and H2S was able to inhibit liver cancer stem cell adhesion. In …
-
Defining the tropism of Listeria monocytogenes using a comparative genomics approach
… array. These included genes with similarities to cystathionine beta-lyase and homoserine O-acetyltransferase, a putative outer-membrane lipoprotein, conserved hypothetical proteins, a peptidoglycan lytic protein and a glycosyltransferase family 65 enzyme. The glycosyltransferase family 65 gene was …
-
Time Delayed Protein Complementation
… tyrosine, histidine, 1- methylhistidine and cystathionine, each contributing <5%. The following amino acids were negatively correlated with growth: threonine, 29.2%; and leucine, phosphoethanolamine, taurine and serine <6.5%. This study confirms previous work in this laboratory which …
-
Maternal rumen-protected methionine supplementation alters dairy calf development, postnatal growth, plasma biomarkers, and liver one-carbon metabolism
… pathway metabolites, concentrations of cystathionine, cysteinesulfinic acid, hypotaurine, serine, and taurine were greater (P ≤ 0.05) in MET calves. There was a treatment day effect for the activity of betaine-homocysteine S-methyltransferase (BHMT), methionine synthase (MTR), and …
-
Regulation of mTORC1 by homocysteine and its effects on autophagy in human and mouse neuronal tissues
… In hyper-homocysteinemic human cells and cystathionine [beta]-synthase-deficient mouse brains, an acute and chronic inhibition of autophagy, the molecular clearance pathway is detected. In Hcy-treated cells, mTORC1 mediates phosphorylation of ULK1 which consequently reduces LC3 lipidation. …
-
Rhizobial infection in nodulation
… with a colleague in the lab. It encodes a Cystathionine Beta-Synthase domain containing protein with a potential role in reactive oxygen species homeostasis. The other mutant, which I named knocks but can’t enter (kce), is blocked at an early stage of infection. I used conventional mapping …
-
Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania
… pathway, involving the action of the enzymes cystathionine β-synthase and cystathionine γ-lyase, to generate cysteine from the essential amino acid methionine. In contrast, Leishmania parasites can synthesise cysteine in two ways but appear unable to salvage it effectively. They contain the …
-
Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge
… (GSS), methionine adenosyltransferase (MAT2), cystathionine β-synthase (CBS), relative weights of liver and spleen, and dual-energy x-ray absorptiometry (DEXA) estimated fat mass (%) and lean mass (%). The differences were considered significant at an alpha level of 0.05. A linear regression …
-
The essentiality of DivIVAEf oligomerization for proper cell division in enterococcus faecalis and interaction with a novel cell division protein
… DivIVAEf and a fragment of MLJD1 containing two cystathionine-beta-synthase (CBS) domains. The in vitro and in vivo results thus confirm interaction between DivIVAEf and MLJD1. Another objective of this study was to determine the localization of DivIVA and MLJD1 in E. faecalis. Localization of …
-
DNA catalysts as phosphatases and as phosphoserine lyases
… to achieve chemo-enzymatic synthesis of a cyclic cystathionine-containing peptide. Based on this initial success, future efforts will be directed to achieve sequence-general phosphoserine and phosphotyrosine lyase activity. Separately, application of sequence-general lyases in the synthesis of …
-
Effect of Hydrogen Sulfide Donors on Sympathetic Neurotransmission and Intraocular Pressure of the Eye
… These included aminooxyacetic acid (AOA), a cystathionine-β-synthase (CBS) inhibitor and glibenclamide, a KATP channel blocker. Although AOA (3mM) and glibenclamide (300 μM) had no effect (p>0.05) on [3H]NE release, they both reversed the inhibitory action of GYY 4137 (10-30 μM), ACS67 (0.1-1 …
-
Physiological and molecular mechanisms associated with performance, immunometabolic status, and liver function in transition dairy cows fed rumen protected methionine or choline
… overall AA profile. Sulfur-containing compounds (cystathionine, cystine, homocystine, and taurine) also were greater (P < 0.05) in MET-supplemented cows, indicating an enriched sulfur-containing compound pool due to enhanced transsulfuration activity. Circulating essential AA (P = 0.06) and total …
Page 1 of 2