Global ETD Search
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Showing 1 to 20 of 21 for “"cyclosome"”.
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Regulation of Anaphase Promoting Complex/Cyclosome to Control M Phase Exit
<p>The Anaphase Promoting Complex/Cyclosome (APC/C) is a RING E3 ligase that plays essential roles both within and outside of the cell cycle. At the onset of anaphase, the APC/C targets cyclin B and securin for degradation, initiating chromosome separation and mitotic exit. Regulation of APC/C …
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The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis
… mediated by the Anaphase-Promoting Complex/ Cyclosome (APC/C). During oogenesis of multicellular organisms, molecular control of meiosis has an added complexity because these divisions must be coordinated with the growth and development of the oocyte as well as its fertilization. The …
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A meiosis-specific form of the Anaphase Promoting Complex/Cyclosome regulates the oocyte-to-embryo transition in Drosophila
… heart of this is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates for degradation, and thus progresses the cell cycle irreversibly forward. Many substrates of the APC/C have been identified in mitosis, but how the APC/C regulates meiosis …
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Design and development of novel antagonists targeting Cdc20, a central regulator of the Anaphase-Promoting Complex/Cyclosome, for the treatment of cancer
… protein, binds the Anaphase-Promoting Complex/Cyclosome (APC/C), a complex capable of stipulating protein destruction, regulating its activity and driving cell cycle progression through orderly APC/C substrate degradation. Key oncogenic roles and aberrant expression among diverse cancers, …
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Meiosis-specific Regulation of the Anaphase-Promoting Complex
… ligase called the Anaphase-Promoting Complex or Cyclosome (APC/C). APC/C-dependent destruction of securin/Pds1 is required to activate separase, a thiol protease that mediates chromosome segregation by cleavage of the cohesin complex. The first meiotic division is preceded by an extended prophase …
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Harnessing the Anaphase-Promoting Complex for Targeted Protein Degradation
… field, namely the anaphase-promoting complex or cyclosome (APC/C). The APC/C is a vital ubiquitin ligase involved in the destruction of numerous proteins including Securin, Cyclin B1 and Aurora kinase A. Most natural APC/C substrates contain multiple copies of short linear motifs (SLiMs), termed …
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Mitotic regulators and their effects on Drosophila : chromosome structure during development
… is a subunit of the anaphase-promoting complex/cyclosome. Increasing levels of cyclin B, a known mitotic target of the APC/C, does not alter the timing of the transition, indicating that CYCLIN B is not the only APC/C target at the polyteny-polyploidy transition. In mitosis, activity of APC/C …
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing APC/C-mediated degradation of two key cell cycle regulators, cyclin B and securin. The MCC is composed of BubR1, Cdc20 and Mad2, and while their …
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The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint
… E3 ligase, anaphase-promoting complex or cyclosome (APC/C). Cdc20 is the mitosis-specific APC/C activator. The spindle checkpoint prevents premature sister chromatids separation by preventing Cdc20 from activating APC/C. Bub1 is a highly conserved spindle checkpoint protein that plays …
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Analysis of Aurora B Regulation and Signaling
… for substrates of the anaphase-promoting complex/cyclosome (APC/C), an ubiquitin ligase essential for mitotic progression. Here, we showed that Aurora B is a substrate of APC/C both in vitro and in vivo. Aurora B is efficiently ubiquitinated iv in an in vitro reconstituted system by APC/C that had …
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Morphological and Neuroanatomical Changes Associated with the Induction of Neurodegeneration and Life Span Reduction in Drosophila melanogaster by Glia Targeted Expression of Cdh1/Rap/Fzr, An Activator of the Anaphase Promoting Complex
… ligase complex: the Anaphase Promoting Complex/Cyclosome (APC/C). APC/C facilitates the cell cycle stage-specific degradation of cyclins and other mitotic regulators, resulting in the inactivation of Cdk (Cyclin Dependent Kinase) complexes, thus promoting completion of mitosis. Previous studies …
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Mechanism of APC/C activation and substrate specificity in mitosis
… controlled by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate …
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Molecular Mechanisms Involved in Chromosome Segregation
… segregation. The anaphase promoting complex/cyclosome (APC/C) is a key regulator of the anaphase transition, and SAC directly inhibits APC/C via a soluble mitotic checkpoint complex (MCC). While many molecular details of APC/C function are now known, recent data suggest that the APC/C is also …
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… Tankyrase (TNKS) the Anaphase Promoting Complex/Cyclosome (APC/C-Cdc20). TNKS belong to the poly-ADP-ribose polymerases (PARP) family of enzymes that PARylate their substrates, leading to ubiquitination and subsequent degradation. TNKS bind their protein substrates through an ankyrin-repeat …
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Eukaryotic chromosome segregation: New aspects of separase regulation by securin, Cdk1, PP2A and auto-cleavage
… apparatus does the anaphase promoting complex or cyclosome (APC/C), a multisubunit E3 ligase, mediate the ubiquitylation of securin and cyclin B1. Their subsequent proteasomal degradation then releases active separase. Murine embryonic stem cells, which lack securin and express a Cdk1-resistant …
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Safeguard of Mitosis: The Spindle Checkpoint
… activity of the anaphase-promoting complex or cyclosome bound to its co-activator Cdc20 (APC/C-Cdc20) to arrest cells in mitosis. Nevertheless, it remains unknown how the checkpoint monitors the status of the kinetochore-microtubule attachment. Neither is clear how MCC is assembled in an active …
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The peptidyl-prolyl isomerase Pin1 is required for maintenance of the spindle assembly checkpoint
… is mediated by the anaphase promoting complex or cyclosome (APC/C), a multisubunit ubiquitin ligase, in conjunction with its essential co-activator Cdc20. The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the chromosomes' interactions with the microtubules of the …
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Identification and functional characterisation of novel APC/C interacting proteins
The anaphase promoting complex /cyclosome (APC/C) is a multi-protein E3 ubiquitin ligase complex that regulates cellular proliferation through its ability to target essential cell cycle regulators such as cyclin A, cyclin B, securin and S-phase kinase-associated protein 2 (SKP2) for …
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Characterisation of the KA1 & KA2 domains and interaction with APC/C
… ligase is the anaphase promoting complex/cyclosome (APC/C) which is responsible for faithful segregation of chromosome during mitosis. Failure to regulate this process can lead to aneuploidy, one of the main causes of cancer. It is therefore important to understand the function and …
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Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex
… the Anaphase Promoting Complex, also called Cyclosome (APC/C), modifies myriad substrates that control cell cycle activities. The APC/C is a ubiquitin ligase complex; it is the final enzyme in a tri-enzyme cascade and catalyzes the final step of Ub transfer from an E2 enzyme directly to …
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