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Showing 1 to 20 of 46 for “"cyclophosphamide"”.
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Inhibition of the Humoral Response by Spleen Cells From Cyclophosphamide Treated Mice
Made available in DSpace on 2014-12-14T13:28:20Z (GMT). No. of bitstreams: 1 7915392.pdf: 3945145 bytes, checksum: 94f77eec7d8f8ff834670fcc7127067c (MD5) Previous issue date: 1979
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Investigation of RNA-Binding Protein Expression Changes in the Hippocampus Following Doxorubicin and Cyclophosphamide Treatment
… impairment (CICI) following doxorubicin and cyclophosphamide treatment in a rat model, revealing three significant alterations in hippocampal tissue: selective downregulation of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) (21% decrease, p=0.0298), compromised astrocytic network …
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Retrospective comparison of cyclophosphamide and mycophenolate mofetil in lupus nephritis at Groote Schuur Hospital nephrology unit
… using mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVCYC) has been reported from studies, but there is limited data in Africans comparing both treatments in patients with proliferative LN. Methods. This was a retrospective study of patients with biopsy-proven proliferative LN …
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Comparison of two neoadjuvant chemotherapy in locally advanced breast cancer patients; Adriamycin and Docetaxel (AD) versus Adriamycin, Cyclophosphamide followed by Paclitaxel (AC-T)
… adriamycin and docetaxel (AD) with adriamycin, cyclophosphamide followed by paclitaxel (AC-T) as neoadjuvant chemotherapy from 1 November 2005 to 31 September2011. The AD group was scheduled for 6 cycles of AD (50mg/m2 and 75mg/m2, respectively) in the interval of 3 weeks. The AC-T group was …
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Validação de método bioanalítico para avaliação da influência da ivermectina e ciclofosfomida na farmacocinética (pk) da carboplatina: ensaio pré-clínico
… in rat plasma and to evaluate the influence of cyclophosphamide on the pharmacokinetics of carboplatin in healthy rats (preclinical pilot test). We studied 24 Wistars rats, divided into three experimental groups: G1 - animals treated with carboplatin alone (n = 8), G2 - animals treated with …
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The development of functional in vitro toxicity tests
… cell after eo-incubation with either dapsone or cyclophosphamide (50µM) and rat liver microsomal metabolite generating system. The pre incubation of the cells with N-ethylmalemide to inhibit Phase II sulphotransferase activity, prior to the microsomal incubations, resulted in cytotoxcity in all …
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A study of acetylcholinesterase and cholinesterase in the fetal mouse brain and a study of the effects of three teratogens, vitamin A, cyclophosphamide and sodium valproate on the fetal mouse central nervous system
… central nervous system teratogens, vitamin A, cyclophosphamide and sodium valproate when administered during embryonic development, on gross fetal parameters in C3H mice including embryolethality, gross morphological abnormalities, fetal weight, brain weight, brain acetylcholinesterase and its …
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Immune parameters as predictors of response to maintenance therapy in low grade non-Hodgkin's lymphoma patients
… chemotherapy for 6 weeks, which consisted of cyclophosphamide, oncovin (vincristine) and prednisone (COP). After this treatment patients received either oral cyclophosphamide or alpha-interferon (α-IFN) as maintenance treatment for a period of two years. The ability to predict patients' …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… abnormalities. Because chemotherapeutics like cyclophosphamide induce dystrophic catagen and alopecia, we hypothesized Egfr mutants would be resistant to alopecia. Mutants arrested in early catagen following cyclophosphamide, sustained less apoptosis, had less p53, and did not undergo alopecia …
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Therapeutic Aerobic Exercise in a Mouse Model of Breast Cancer: Effects on Tumor Progression, Angiogenesis, and Response to Chemotherapy
… decreased hypoxia and increased effectiveness of cyclophosphamide chemotherapy </p><p>To investigate the effects of exercise on tumor microenvironment, we injected syngeneic 4T1 breast tumor cells into the mammary fat pad of immunocompetent BALB/c mice. The exercise intervention (voluntary wheel …
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Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
… sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat various recalcitrant forms of cancer. When activated, cyclo-phosphamide forms aldophosphamide that can spontaneously form the toxic …
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ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΗΜΙΟΛΟΓΙΑΣ ΚΑΙ ΤΗΣ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΟΥ ΑΦΡΟΔΙΣΙΟΥ ΜΕΤΑΔΟΤΙΚΟΥ ΝΕΟΠΛΑΣΜΑΤΟΣ ΣΤΟ ΣΚΥΛΟ
… CONSISTED OF THE ADMINISTRATION OF VINCRISTINE, CYCLOPHOSPHAMIDE AND METHOTREXATE, AND IN 140 DOGS OF VINCRISTINE ONLY. IN 18 CASES TREATMENT CONSISTED OF REMOVAL OF NEOPLASTIC TISSUES BY MEANS OF SURGERY. ALL THE ANIMALS OF THE FIRST GROUP WERE CURED; THERE WERE NO RELAPSES OF THE NEOPLASM IN …
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Development of a new screening assay to identify proteratogenic compounds using Zebrafish Danio rerio embryo combined with an exogenous mammalian metabolic activation system (mDarT)
… able to biotransform proteratogenic compounds. Cyclophosphamide, ethanol, benzo[a]pyrene and thalidomide were used as test materials to assess the efficiency of this assay. Briefly, the zebrafish embryos were co-cultured at 2 hpf (hours post fertilization) with the test material at varying …
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Arsenic in drinking water caused ultra-structural damage in urinary bladder but did not affect expression of DNA damage repair genes or repair of DNA damage in transitional cells
… Dimethylarsinic acid did not affect in vivo cyclophosphamide-induced DNA damage, and neither DMA(V) nor arsenate inhibited in vitro repair of hydrogen peroxide- or formaldehyde-induced DNA damage, as measured by Comet assay. Neither DMA(V) nor arsenate increased MN or elevated in vivo …
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Modeling hematologic malignancies and their treatment in humanized mice
… with the commonly used chemotherapeutic agent cyclophosphamide. Great synergy between alemtuzumab and cyclophosphamide seen in this model suggests that a further investigation into this clinically relevant drug combination is well warranted.
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Modelling and Investigation of Drug and Immune Therapies for Cancer
… between cancer cells and a chemotherapy drug (Cyclophosphamide), and use it to confirm (in combination with experimental data for tumour growth) that Cyclophosphamide has nonlinear drug decay.<br/><br/>The second investigation presents a mathematical model to illustrate the dynamics of immune …
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Cost-Effectiveness Analysis of Tisagenlecleucel, Blinatumomab, and Clofarabine for Treatment of B-cell Precursor Acute Lymphoblastic Leukemia
… of tisagenlecleucel; clofarabine, etoposide, cyclophosphamide; and blinatumomab for the treatment of relapse- refractory ALL for adolescents and young adults from the U.S. health care payer perspective. Material and Methods</p> <p>Clinical data were collected from the FDA databases, RedBook …
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The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours
… von Tumoren durch geringe Konzentrationen von Cyclophosphamide (Cy). Diese Arbeit zeigt, daß haematopoetische Zellen IFN-g produzieren, welches für die Abstoßung von Tumoren notwendig ist. Mit Hilfe des Cincinnati Zytokin Capture Assay gelang es nachzuweisen, daß die Verabreichung von Cy zu …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
… enhanced drug-induced cytotoxicity of Cyclophosphamide, Dexamethasone and Vincristine. Furthermore, we report an <em>in vitro</em> and <em>in vivo</em> CXCR4 genetic deletion model of B-ALL cells generated using the CRISPR-Cas9 gene editing technology. The CXCR4 Knockout cells display …
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