Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cyclophilin A"”.
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… spectrometric analysis reveals that secreted cyclophilin A (CYPA) is upregulated in the CM by XRCC3-siRNAs. The addition of recombinant CYPA to naïve T4-2 cells enhances their invasiveness, suggesting that CYPA is sufficient to induce neighboring cell invasiveness. Inhibiting the secreted CYPA …
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Endotelinių mikrodalelių tyrimas pirminėje ląstelių kultūroje /
… shed from endothelial cells effected by cyclophilin A in vitro. Healthy subjects were divided into two groups according to cholesterol concentration. Results have shown that in lower cholesterol concentration group, high sistolic blood pressure positively correlated with EMV CD105+. …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
<p>Cyclophilin A are a class of peptidyl-prolyl isomerases that catalyzes isomerization of the proline residue within a protein. Cyclophilin A plays an instrumental role in the pathogenesis of HIV and HCV virus. Using structure-based drug we designed and synthesized small molecule inhibitors of …
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Analisi Molecolare del Melanoma
… regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these molecules are overexpressed in melanoma. Different protein profiles were also found between each individual melanoma cell line and the melanocytes. …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… DENV-2 is independent of its target proteins, cyclophilin A or B, which are not required host factors for DENV-2 in Huh7 and A549 cells. In Huh7 and A549 cells, CsA induces interferon regulatory factor-1 (IRF1)-dependent antiviral gene expression. While CsA does not increase IRF1 levels in Huh7 …
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The Proteomic Response of the Carcinus maenas Y-organ Over the Course of the Molt Cycle
… mechanism through which ROS-induced release of cyclophilin A may contribute to YO atrophy during postmolt through the remodeling of structural proteins such as collagen. We support the standing observation of YO atrophy during postmolt by drawing attention to hemolymph protein abundances, …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… lipocalin) and cytoplasmic (cyclophilin A) proteins under hypoxia. Furthermore, a plasma signature of increased protease (NE and proteinase 3) activity was identified in COPD versus healthy control plasma. In conclusion, hypoxia engenders a destructive neutrophil phenotype, …
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Engineering fluorescent imaging platforms to characterise molecular interactions with HIV-1 capsid
… confirmed that binding of the host cell protein cyclophilin A (CypA) to the tubular lattice is substoichiometric due to steric hindrance between CypA molecules. Binding analysis of cleavage and polyadenylation specificity factor subunit 6 (CPSF6) expressed as a full-length protein in a cell-free …
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Progress Towards Integrated Models of HCV Dynamics
… a surprising role for the host cellular protein cyclophilin A in regulating virus assembly as well as clarifying aspects of NS5A phosphorylation. These findings suggest a complex system of regulation linking polyprotein translation, RNA replication, and virion assembly which will require further …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
… ESC cultures, and that one of these factors is Cyclophilin A. Finally, we demonstrate that changes in the low molecular weight composition of the medium are likely responsible for the decrease in growth at high plating densities (>104 cells/cm2). We use a numerical model to show that competition …
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Factors affecting replication and cross-species transmission of feline immunodeficiency virus
… an effect that is enhanced by host factor cyclophilin A (CypA), but largely evades restriction by the human TRIM5α variant. HIV-1 replication is also inhibited by simian APOBEC3G but is able to evade restriction by human APOBEC3G by inducing its degradation through expression of accessory …
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The effect of overfeeding and obesity on canine adipose tissue and skeletal muscle transcriptomes
… weight range (3.0-29.5 kg). ZAG expression (ZAG/cyclophilin A) ranged from 0.68-3.13, but there was no influence (P>0.05) of body condition score or body weight on its expression. Gonadal adipose tissue expression of ZAG was not influenced by body condition score in this clinical population, …
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TRIM5α is a poxvirus restriction factor: viral evasion strategies and a pathway to antivirals
… reports that VACV exploits the cellular protein, cyclophilin A (CypA), as an additional measure to counteract TRIM5α-mediated restriction. This work was based on prior observations that CypA is utilised by HIV-1 to evade restriction by human TRIM5α, CypA is incorporated into both VACV and HIV-1 …