Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"cyclooxygenases"”.
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
Neuropathic pain is caused by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more …
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Expression and Function of a Putative Cox-Like Gene in D. melanogaster
<p>Cyclooxygenases (COX) are the enzymes that catalyze the conversion of arachidonic acid into prostaglandins. In mammals, isoform COX-1 is constitutively expressed, whereas the isoform COX-2 gene expression is induced, primarily at sites of inflammation. While eicosanoids play a major role in …
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The mechanism of action of the anticancer effects of selenomethionine on colon cancer
… might affect cell growth by mechanisms involving cyclooxygenases, specifically the inducible isoform COX-2. Cyclooxygenases (COX-1 and COX-2) are enzymes that metabolize arachidonic acid to various prostaglandins. The human adenocarcinoma cell lines HT-29 and HCA-7, that express variable levels of …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
… consequence of simultaneously inhibiting both cyclooxygenases (COX) -1 and -2 to suppress prostaglandin synthesis. Operating under this assumption, I had developed a novel mouse model of inducible COX-1 + COX-2 deletion to complement our lab’s chronic NSAID exposure model. These COX …
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An investigation of the neuroprotective properties of fenamate NSAIDs, against experimental model of ischemic stroke
… <p>Fenamates are non-selective inhibitors of cyclooxygenases. In addition, fenamates are antagonists of non-selective cation channels, subtype-selective modutators of GABA<sub>A </sub>receptors, weak inhibitors of glutaniate receptors and activators of some potassium channels, all potentially …
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Elucidating the Interplay Between Lipids and Membrane Proteins Using Multiscale Computer Simulations
… interaction profile of AMPA receptors and cyclooxygenases (mainly COX-1), showing that they both form specific interactions with lipids, but do so in a quite different fashion. AMPA receptors interact specifically with diacylglycerol lipids, whereas COX-1 enzymes do so indiscriminately with …
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A Combined Computational Strategy of Sequence and Structural Analysis Predicts the Existence of a Functional Eicosanoid Pathway in <i>Drosophila melanogaster</i>
… eight low confidence candidates. Four predicted cyclooxygenases and two potential lipoxygenase activating proteins, highly divergent from their human counterparts, were identified, although similar methods failed to identify putative lipoxygenase enzymes. Tertiary structures of a majority of …
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Regulation of tumour necrosis factor receptor expression on neutrophils by arachidonic acid and other long chain fatty acids.
… not sensitive to the action of inhibitors of the cyclooxygenases and lipoxygenases. Using chemical inhibitors of intracellular signaling pathways, we demonstrate that the effect of AA on TNFRI is very sensitive to GFI09203X, PD098059, AACOCF3 and wortmannin, showing a role for protein kinase C, …